Skeletal blood flow, iliac histomorphometry, and strontium kinetics in osteoporosis: a relationship between blood flow and corrected apposition rate
In 20 untreated patients with idiopathic or postmenopausal osteoporosis, kinetic studies of skeletal blood flow (using /sup 18/F) and bone turnover (using /sup 85/Sr) were combined with dynamic histomorphometry performed on transiliac biopsies taken within 6 weeks of each other. In 8 patients the combined studies were repeated after treatment. A further 5 patients were studied only while receiving treatment. As expected, skeletal blood flow measured by /sup 18/F correlated with an index of /sup 85/Sr uptake into the exchangeable pools of bone. Additionally and independently, skeletal blood flow correlated with an index of the work rate of the osteoblasts in each multicellular unit of bone (the corrected apposition rate of Parfitt). These correlations were statistically significant in both the untreated patients (P less than 0.05) and the whole group (P less than 0.001). Further indices related to bone turnover at the level of the skeleton as a whole were significantly associated with skeletal blood flow only in the combined group.
- Research Organization:
- Medical Research Council Clinical Research Centre, Harrow (England)
- OSTI ID:
- 7139047
- Journal Information:
- J. Clin. Endocrinol. Metab.; (United States), Vol. 66:6
- Country of Publication:
- United States
- Language:
- English
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OSTEOPOROSIS
PATHOGENESIS
SKELETON
BLOOD FLOW
CALCIUM
FLUORINE 18
PATIENTS
STRONTIUM 85
TRACER TECHNIQUES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
METALS
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
SKELETAL DISEASES
STRONTIUM ISOTOPES
550901* - Pathology- Tracer Techniques