Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake
Ionizing radiation induces hypothermia in guinea pigs. While systemic injection of the radioprotectant S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) did not block hyperthermia induced by exposure to 10 Gy of gamma radiation, central administration did attenuate it. The dephosphorylated metabolite of WR-2721, N-(2-mercaptoethyl)-1,3-diaminopropane (WR-1065), accentuated radiation-induced hypothermia by both routes of administration. In brain homogenates, oxygen uptake was inhibited by WR-2721 but elevated by WR-1065. These results suggest that the antagonism of radiation-induced hypothermia found only after central administration of WR-2721 is due to its direct actions and not to its dephosphorylated metabolite and that this effect may be correlated with the inhibition by WR-2721 of oxygen uptake.
- Research Organization:
- Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
- OSTI ID:
- 7138678
- Journal Information:
- Radiat. Res.; (United States), Vol. 114:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparative study of the radioprotective effects of cysteamine, WR-2721, and WR-1065 in cultured human cells. [Reproductive death of cells following. gamma. irradiation used as indicator]
Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721
Related Subjects
HYPOTHERMIA
RADIOINDUCTION
OXYGEN
UPTAKE
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
BRAIN
GAMMA RADIATION
GUINEA PIGS
ANIMALS
BODY
BODY TEMPERATURE
CENTRAL NERVOUS SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
IONIZING RADIATIONS
MAMMALS
NERVOUS SYSTEM
NONMETALS
ORGANS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals