The Huntington disease locus is most likely within 325 kilobases of the chromosome 4p telomere

Journal Article · Fri Dec 01 00:00:00 EST 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.24.10011· OSTI ID:7137814

Doggett, N A; Cheng, J F; Smith, C L; Cantor, C R ^[1]

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1. Columbia Univ., New York, NY (USA)

The genetic defect responsible for Huntington disease was originally localized near the tip of the short arm of chromosome 4 by genetic linkage to the locus D4S10. Several markers closer to Huntington disease have since been isolated, but these all appear to be proximal to the defect. A physical map that extends from the most distal of these loci, D4S90, to the telomere of chromosome 4 was constructed. This map identifies at least two CpG islands as markers for Huntington disease candidate genes and places the most likely location of the Huntington disease defect remarkably close (within 325 kilobases) to the telomere.

• OSTI ID: 7137814
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:24; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HEREDITARY DISEASES
GENETIC MAPPING
HETEROCHROMOSOMES
AUTORADIOGRAPHY
DNA HYBRIDIZATION
ELECTROPHORESIS
NERVOUS SYSTEM DISEASES
PATIENTS
PHOSPHORUS 32
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHROMOSOMES
DAYS LIVING RADIOISOTOPES
DISEASES
HYBRIDIZATION
ISOTOPES
LIGHT NUCLEI
MAPPING
NUCLEI
ODD-ODD NUCLEI
PHOSPHORUS ISOTOPES
RADIOISOTOPES
550401* - Genetics- Tracer Techniques