Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection

Journal Article · Thu Mar 01 00:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:7137586

Palestro, C J; Vega, A; Kim, C K; Vallabhajosula, S; Goldsmith, S J ^[1]

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1. Mt. Sinai School of Medicine, New York, NY (USA)

Bacterial sepsis, a significant complication of chronic hemodialysis, is generally the result of infection at the vascular access site. We retrospectively reviewed the utility of indium-111-(111In) labeled autologous leukocyte scintigraphy in 26 patients (30 scans) with synthetic vascular grafts, on chronic hemodialysis, in whom hemodialysis access site infection was a diagnostic consideration. Leukocyte scintigraphy correctly identified all fifteen access-site infections; there was one false-positive study, for an overall sensitivity and specificity of 100% and 93%, respectively. Of particular significance is the fact that in nine (60%) of the fifteen access-site infections, physical examination was normal. Our data indicate that 111In-labeled leukocyte scintigraphy is a useful procedure for the diagnosis of hemodialysis access-site infection, and it is especially valuable when physical examination of the access site is normal.

• OSTI ID: 7137586
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:3; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BACTERIAL DISEASES
DIAGNOSIS
LEUKOCYTES
SCINTISCANNING
BLOOD VESSELS
DIALYSIS
INDIUM 111
PATIENTS
SENSITIVITY ANALYSIS
SPECIFICITY
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
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BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SEPARATION PROCESSES
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