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Title: Effect of histocompatibility factors on pulmonary retention of indium-111-labeled granulocytes

Abstract

Granulocyte transfusions are associated with a number of side effects including febrile transfusion reactions and occasionally pulmonary infiltrates. There is evidence that the presence of preformed antibodies may be a cause of these complications. In this study, allogeneic 111Indium-labeled granulocytes were used to evaluate the pulmonary retention of radioactivity in alloimmunized and non-alloimmunized patients in an attempt to assess antibody effect on granulocyte migration. After injection of labeled allogeneic granulocytes into neutropenic patients, the ratios of lung to heart activity were calculated for the first 30 min of scanning. There was significantly greater retention of radioactivity from cells in the lungs of patients who were alloimmunized, having both lymphocytotoxic (anti-HLA) and leuko-agglutinating antibodies, compared to the activity in the lungs of non-alloimmunized patients (P less than .001) or of patients receiving autologous granulocytes (P less than .001). This study demonstrates that labeled, mismatched granulocytes may be retained in the lungs for a significantly longer time in patients with preformed antibodies. This implies that transfusion of large numbers of such mismatched granulocytes, i.e., granulocyte transfusions, may also be retained in the lungs of alloimmunized patients, which could lead to pulmonary compromise. Therefore, granulocyte transfusions from random donors should not be givenmore » to alloimmunized patients.« less

Authors:
; ; ; ; ; ;  [1]
  1. Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY (USA)
Publication Date:
OSTI Identifier:
7137371
Resource Type:
Journal Article
Journal Name:
American Journal of Hematology; (USA)
Additional Journal Information:
Journal Volume: 33:4; Journal ID: ISSN 0361-8609
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LEUKOCYTES; RETENTION; LUNGS; RADIOISOTOPE SCANNING; ANTIBODIES; BLOOD; IMMUNE REACTIONS; INDIUM 111; PATIENTS; TRANSFUSIONS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD CELLS; BODY; BODY FLUIDS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RESPIRATORY SYSTEM; THERAPY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Dutcher, J P, Riggs, C Jr, Fox, J J, Johnston, G S, Norris, D, Wiernik, P H, and Schiffer, C A. Effect of histocompatibility factors on pulmonary retention of indium-111-labeled granulocytes. United States: N. p., 1990. Web. doi:10.1002/ajh.2830330405.
Dutcher, J P, Riggs, C Jr, Fox, J J, Johnston, G S, Norris, D, Wiernik, P H, & Schiffer, C A. Effect of histocompatibility factors on pulmonary retention of indium-111-labeled granulocytes. United States. https://doi.org/10.1002/ajh.2830330405
Dutcher, J P, Riggs, C Jr, Fox, J J, Johnston, G S, Norris, D, Wiernik, P H, and Schiffer, C A. 1990. "Effect of histocompatibility factors on pulmonary retention of indium-111-labeled granulocytes". United States. https://doi.org/10.1002/ajh.2830330405.
@article{osti_7137371,
title = {Effect of histocompatibility factors on pulmonary retention of indium-111-labeled granulocytes},
author = {Dutcher, J P and Riggs, C Jr and Fox, J J and Johnston, G S and Norris, D and Wiernik, P H and Schiffer, C A},
abstractNote = {Granulocyte transfusions are associated with a number of side effects including febrile transfusion reactions and occasionally pulmonary infiltrates. There is evidence that the presence of preformed antibodies may be a cause of these complications. In this study, allogeneic 111Indium-labeled granulocytes were used to evaluate the pulmonary retention of radioactivity in alloimmunized and non-alloimmunized patients in an attempt to assess antibody effect on granulocyte migration. After injection of labeled allogeneic granulocytes into neutropenic patients, the ratios of lung to heart activity were calculated for the first 30 min of scanning. There was significantly greater retention of radioactivity from cells in the lungs of patients who were alloimmunized, having both lymphocytotoxic (anti-HLA) and leuko-agglutinating antibodies, compared to the activity in the lungs of non-alloimmunized patients (P less than .001) or of patients receiving autologous granulocytes (P less than .001). This study demonstrates that labeled, mismatched granulocytes may be retained in the lungs for a significantly longer time in patients with preformed antibodies. This implies that transfusion of large numbers of such mismatched granulocytes, i.e., granulocyte transfusions, may also be retained in the lungs of alloimmunized patients, which could lead to pulmonary compromise. Therefore, granulocyte transfusions from random donors should not be given to alloimmunized patients.},
doi = {10.1002/ajh.2830330405},
url = {https://www.osti.gov/biblio/7137371}, journal = {American Journal of Hematology; (USA)},
issn = {0361-8609},
number = ,
volume = 33:4,
place = {United States},
year = {Sun Apr 01 00:00:00 EST 1990},
month = {Sun Apr 01 00:00:00 EST 1990}
}