Ocular sensitization of mice by live (but not irradiated) Chlamydia trachomatis serovar A
Ocular exposure of mice to live elementary bodies of Chlamydia trachomatis serovar A results in immunological sensitization of the mice. This reactivity is manifested by the development of early (5 h) and delayed-type (24 h) dermal reactivity and serovar-specific antibody formation against either live or irradiated (100 kilorads) elementary bodies. Parallel ocular exposure of mice to irradiated elementary bodies does not result in this sensitization. The early and late dermal immune responses induced by ocular exposure to live organisms can be transferred to unexposed mice by serum and lymphoid cell transfers, respectively. It appears that successful murine ocular sensitization by human C. trachomatis serovar A elementary bodies is an ability manifested by live organisms and not by inactivated but antigenic organisms.
- Research Organization:
- Vanderbilt Univ. School of Medicine, Nashville, TN
- OSTI ID:
- 7132982
- Journal Information:
- Infect. Immun.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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EYES
IMMUNE REACTIONS
MICROORGANISMS
IRRADIATION
ANTIBODIES
CONJUNCTIVA
IMMUNITY
LYMPHOCYTES
MICE
SKIN
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
FACE
HEAD
LEUKOCYTES
MAMMALS
MATERIALS
MEMBRANES
MUCOUS MEMBRANES
ORGANS
RODENTS
SENSE ORGANS
SOMATIC CELLS
VERTEBRATES
560130* - Radiation Effects on Microorganisms