Red blood cell labeling with technetium-99m. Effect of radiopaque contrast agents

Journal Article · Tue Mar 01 00:00:00 EST 1988 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198803000-00004· OSTI ID:7125927

Finkel, J; Chervu, L R; Bernstein, R G; Srivastava, S C

Radiographic contrast agents have been reported in the literature to interfere significantly with red blood cell (RBC) labeling in vivo by Tc-99m. Moreover, in the presence of contrast agents, red cells have been known to undergo significant morphologic changes. These observations led to the current RBC labeling study in patients (N = 25) undergoing procedures with the administration of contrast media. Before and after contrast administration, blood samples were drawn from each patient into vacutainer tubes containing heparin and RBC labeling was performed using 1-ml aliquots of these samples following the Brookhaven National Laboratory protocol. The differences in average percentage labeling yield with and without contrast media were not significant. In vivo labeling in hypertensive rats with administration of contrast media up to 600 mg likewise consistently gave high labeling yields at all concentrations. Purported alterations in cell labeling attributed to contrast agents are not reflected in these studies, and other pathophysiologic factors need to be identified to substantiate the previous reports. In vitro study offers a potentially useful and simple method to delineate effects of various agents on cell labeling.

• Research Organization: Albert Einstein College of Medicine, Bronx, NY (USA)
• OSTI ID: 7125927
• Journal Information: Clin. Nucl. Med.; (United States), Vol. 13:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CONTRAST MEDIA
BIOLOGICAL EFFECTS
ERYTHROCYTES
LABELLING
HYPERTENSION
IMAGE PROCESSING
ISOMERIC NUCLEI
PATIENTS
RATS
TECHNETIUM 99
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARDIOVASCULAR DISEASES
DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
PROCESSING
RADIOISOTOPES
RODENTS
SYMPTOMS
TECHNETIUM ISOTOPES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics