Assessment of cardiopulmonary alterations in endotoxic shock

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Am. J. Physiol. Imag.; (United States)

OSTI ID:7125742

Christenson, J T; Kuikka, J; Al-Sarraf, A A; Owunwanne, A

Using radionuclide first-pass technique, seven sheep were studied prior to and during endotoxic shock. In vitro labeled /sup 99m/TC red blood cells were used to measure right and left ventricular ejection fractions (RVEF and LVEF) and cardiopulmonary transit time (CPTT) prior to and at 1, 4, 30, and 60 minutes after the intravenous injection of endotoxin Escherichia coli, 3 mg/kg bodyweight. The LVEF decreased slightly from 51 to 42% but became normal four minutes later, while the RVEF remained decreased from 49 to 26% for 60 minutes. The CPTT was prolonged from 13 to 26 cardiac beats. The decrease in RVEF was well correlated with the prolongation of the CPTT.

• Research Organization: Kuwait Univ., Safat
• OSTI ID: 7125742
• Journal Information: Am. J. Physiol. Imag.; (United States), Vol. 1:4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL SHOCK
TRACER TECHNIQUES
ENDOTOXINS
BIOLOGICAL EFFECTS
VASCULAR DISEASES
PATHOGENESIS
CARDIOVASCULAR SYSTEM
ERYTHROCYTES
ESCHERICHIA COLI
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
LABELLED COMPOUNDS
RESPIRATORY SYSTEM
SHEEP
TECHNETIUM 99
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DISEASES
DOMESTIC ANIMALS
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPES
RUMINANTS
TECHNETIUM ISOTOPES
TOXIC MATERIALS
TOXINS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550901* - Pathology- Tracer Techniques