(. mu. -1,1 prime -Bis(diphenylphosphine)ferrocene)bis(chlorogold): Synthesis, iron-57 and gold-197 Moessbauer spectroscopy, x-ray crystal structure, and antitumor activity
- Smith Kline and French Labs., King of Prussia, PA (USA)
- Northeastern Univ., Boston, MA (USA)
The title compound 2, Fdpp(AuCl){sub 2}, synthesized via the addition of Fdpp (1) to an aqueous solution of ((HOCH{sub 2}CH{sub 2}){sub 2}S)AuCl generated in situ by the thiodiglycol reduction of HAuCl{sub 4} showed a {sup 31}P({sup 1}H) NMR chemical shift at {delta} 27.39, which was downfield from that of 1 at {delta} -17.34 relative to (CH{sub 3}O)PO. The {sup 57}Fe Moessbauer spectrum of 2 is a doublet with parameters (IS = 0.50 mm/s relative to Fe, QS = 2.33 mm/s) similar to those of ferrocene. The {sup 197}Au Moessbauer spectrum of 2 is an asymmetric doublet (QS = 6.93 mm/s) with an IS of 3.81 mm/s relative to Au metal. Fdpp(AuCl){sub 2} crystallized in space group P{bar 1} with lattice constants a = 16.192 (4) {angstrom}, b = 16.921 (4) {angstrom}, and c = 10.878 (5) {angstrom} with Z = 3. Two crystallographically independent molecules, A and B, were observed in the structure of 2 with a chloroform solvate molecule per 1.5 formula units of the gold complex. For A, the P atoms are 180{degree} opposed and the rings exactly staggered, while in B the P atoms are 150{degree} apart and the rings are partially staggered. The P-Au-Cl linkage is nearly linear, and the bond distances fall within normal ranges. Evaluation in an ip P388 leukemia mouse model showed 1 and 2 to have only marginal activity with an increased life span (ILS) relative to untreated controls of 30% at a maximally tolerated dose (MTD) of 231 {mu}mol/kg and 40% ILS at 4 {mu}mol/kg, respectively. 27 refs., 4 figs., 3 tabs.
- OSTI ID:
- 7108010
- Journal Information:
- Inorganic Chemistry; (USA), Vol. 28:18; ISSN 0020-1669
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
FERROCENE
SYNTHESIS
GOLD CHLORIDES
ORGANIC PHOSPHORUS COMPOUNDS
CRYSTAL STRUCTURE
EXPERIMENTAL DATA
GOLD 197
INHIBITION
IRON 57
LEUKEMIA
MICE
MOESSBAUER EFFECT
NEOPLASMS
ANIMALS
CHLORIDES
CHLORINE COMPOUNDS
COMPLEXES
DATA
DIENES
DISEASES
EVEN-ODD NUCLEI
GOLD COMPOUNDS
GOLD ISOTOPES
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HEMIC DISEASES
HYDROCARBONS
IMMUNE SYSTEM DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
IRON COMPLEXES
IRON ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
POLYENES
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
400201* - Chemical & Physicochemical Properties
400202 - Isotope Effects
Isotope Exchange
& Isotope Separation
550600 - Medicine