The effect of dietary sulfur on the metabolism of long chain polyunsaturated fatty acids
The effect of methionine-supplemented diet on the metabolism of polyunsaturated fatty acids was studied by comparing results of control and cysteine-supplemented diets in rats. Adult Sprague-Dawley rats were fed for a period of 17 days one of the following diets: control, cysteine-supplemented, and/or methionine-supplemented. On the last day of the feeding period, the rats were administered either (1-{sup 14}C) arachidonic acid (AA) or (1-{sup 14}C) eicosapentaenoic acid (EPA) by stomach tube five hours before sacrificing. The cyclooxygenase activity in liver microsomes, the apparent Km of the fatty acyl-CoA synthetase in liver and brain homogenates, and the incorporation of polyunsaturated fatty acids into the phosphatidylinositol fraction of brain, heat, lung, spleen, and kidney tissues were analyzed.
- Research Organization:
- Teledyne Brown Engineering, Huntsville, AL (USA)
- OSTI ID:
- 7105575
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARBOXYLIC ACIDS
METABOLISM
METHIONINE
BIOLOGICAL EFFECTS
OXYGENASES
ENZYME ACTIVITY
ARACHIDONIC ACID
CARBON 14 COMPOUNDS
CYSTEINE
DIET
EICOSANOIC ACID
LIGASES
MICROSOMES
RATS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
AMINO ACIDS
ANIMALS
CELL CONSTITUENTS
DISTRIBUTION
DRUGS
ENZYMES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
OXIDOREDUCTASES
RIBOSOMES
RODENTS
THIOLS
VERTEBRATES
550501* - Metabolism- Tracer Techniques