Kinetics and quantitation of In-111 labeled platelet deposition on control and heparin-bonded polyurethane angio catheters in a dog model

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · ASAIO Transactions (American Society for Artificial Internal Organs); (USA)

DOI:https://doi.org/10.1097/00002480-198907000-00062· OSTI ID:7105556

Dewanjee, M K; Rowland, S M; Robinson, R P; Dewanjee, P K; Halgovich, J L; Kapadvanjwala, M; MacGregor, D C; Serafini, A N; Palatianos, G M; Sfakianakis, G N ^[1]

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1. Univ. of Miami, FL (USA)

The dynamics of platelet deposition on control polyurethane catheters (CPC) and heparin-bonded polyurethane catheters (HBPC) were evaluated with In-111 labeled platelets (In-PLT) using a computerized gamma camera (CGC). Ten nonheparinized dogs (18-25 kg) had both femoral arteries catherized with 10 cm of CPC and HBPC (5 Fr.) 24 hr postinjection of 300-420 microcuries of In-PLT, and imaged for 3 hr with a gamma camera. Regional platelet deposition on three segments of catheters and the puncture site was determined. Catheters were harvested and radioactivity on the catheter segments (proximal: PROX, middle: MID, distal: DIST and puncture site: PS) of both was determined. From the platelet count in blood, and radioactivity in blood and segments of catheters, adjacent artery, and area of artery and catheter, the platelet-density (X10(3) (mean +/- S.D.)) on catheter and artery was calculated and tabulated. Proximal values were cath (CPC), 1289 +/- 1125; artery, 1355 +/- 587; cath (HBPC), 125 +/- 113; artery, 1149 +/- 1620. The middle values were cath (CPC), 1102 +/- 1109; artery, 1512 +/- 625; cath (HBPC), 132 +/- 108; artery, 1011 +/- 942. Distal values were cath (CPC), 780 +/- 584; artery, 132 +/- 108; cath (HBPC), 227 +/- 194; artery, 1457 +/- 1309. The puncture site values were cath (CPC), 106 +/- 382; artery, 1011 +/- 942; cath (HBPC), 164 +/- 135; artery, 1498 +/- 1240. The large standard deviation in retained platelets is due to embolization. The platelet-density and regional counts on catheter segments were lower with HBPC than CPC, as was the rate of platelet-deposition.

• OSTI ID: 7105556
• Journal Information: ASAIO Transactions (American Society for Artificial Internal Organs); (USA), Vol. 35:3; ISSN 0889-7190
• Country of Publication: United States
• Language: English

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