Blood cell labeling with sup 99m Tc: Progress and perspectives

Srivastava, S C; Straub, R F

doi:10.1016/S0001-2998(05)80175-8

Title: Blood cell labeling with sup 99m Tc: Progress and perspectives

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Abstract

Blood cell labeling with {sup 99m}Tc has progressed through various developmental phases. In the case of red cell labeling, the science seems to have matured sufficiently, although minor refinements in the procedures will no doubt continue to be made. During the last 3 to 5 years, there has been a resurgence of interest in labeling leukocytes and platelets with {sup 99m}Tc. As a result of these efforts, the techniques for these cell types appear to be developing slowly, having finally come out of their infancy. Progress in these directions over the last 3 1/2 years is summarized and discussed in this article. Emerging techniques that offer the promise of combining simplicity and convenience with reliable and reproducible data are highlighted. Mechanisms involved in the various labeling approaches, if studied and understood, are included. Recent efforts on cell labeling with {sup 99m}Tc using the monoclonal antibody approach are summarized. Although results in this area are quite preliminary, the monoclonal antibody approach holds the greatest promise for labeling leukocytes and platelets in vivo, and thus overcoming the biggest drawback of current techniques, ie, cell separation and handling before labeling. 78 references.

Authors:

Srivastava, S C; Straub, R F ^[1]

Brookhaven National Lab., Upton, NY (USA)

Publication Date:: Mon Jan 01 00:00:00 EST 1990

OSTI Identifier:: 7105464

Resource Type:: Journal Article

Journal Name:: Seminars in Nuclear Medicine; (USA)

Additional Journal Information:: Journal Volume: 20:1; Journal ID: ISSN 0001-2998

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD CELLS; LABELLING; TECHNETIUM 99; TRACER TECHNIQUES; BLOOD PLATELETS; ERYTHROCYTES; ISOMERIC NUCLEI; LEUKOCYTES; MONOCLONAL ANTIBODIES; REVIEWS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; DOCUMENT TYPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats


                    Srivastava, S C, and Straub, R F. Blood cell labeling with sup 99m Tc: Progress and perspectives.  United States: N. p., 1990. 
        Web.  doi:10.1016/S0001-2998(05)80175-8.

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                    Srivastava, S C, & Straub, R F. Blood cell labeling with sup 99m Tc: Progress and perspectives.  United States.  https://doi.org/10.1016/S0001-2998(05)80175-8

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                    Srivastava, S C, and Straub, R F. 1990.  
        "Blood cell labeling with sup 99m Tc: Progress and perspectives".  United States.  https://doi.org/10.1016/S0001-2998(05)80175-8.

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@article{osti_7105464,

  title        = {Blood cell labeling with sup 99m Tc: Progress and perspectives},

  author       = {Srivastava, S C and Straub, R F},

  abstractNote = {Blood cell labeling with {sup 99m}Tc has progressed through various developmental phases. In the case of red cell labeling, the science seems to have matured sufficiently, although minor refinements in the procedures will no doubt continue to be made. During the last 3 to 5 years, there has been a resurgence of interest in labeling leukocytes and platelets with {sup 99m}Tc. As a result of these efforts, the techniques for these cell types appear to be developing slowly, having finally come out of their infancy. Progress in these directions over the last 3 1/2 years is summarized and discussed in this article. Emerging techniques that offer the promise of combining simplicity and convenience with reliable and reproducible data are highlighted. Mechanisms involved in the various labeling approaches, if studied and understood, are included. Recent efforts on cell labeling with {sup 99m}Tc using the monoclonal antibody approach are summarized. Although results in this area are quite preliminary, the monoclonal antibody approach holds the greatest promise for labeling leukocytes and platelets in vivo, and thus overcoming the biggest drawback of current techniques, ie, cell separation and handling before labeling. 78 references.},

  doi          = {10.1016/S0001-2998(05)80175-8},

  url          = {https://www.osti.gov/biblio/7105464},
  journal      = {Seminars in Nuclear Medicine; (USA)},

  issn         = {0001-2998},

  number       = ,

  volume       = 20:1,

  place        = {United States},

  year         = {Mon Jan 01 00:00:00 EST 1990},

  month        = {Mon Jan 01 00:00:00 EST 1990}

}

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