Effects of sustained exercise on pulmonary clearance of aerosolized sup 99m Tc-DTPA

Journal Article · Wed Nov 01 00:00:00 EST 1989 · Journal of Applied Physiology (1985); (USA)

OSTI ID:7105242

Lorino, A M; Meignan, M; Bouissou, P; Atlan, G ^[1]

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1. Institut National de la Sante et de la Recherche Medicale Unite 296, Creteil (France)

The effects of intensive prolonged exercise on the pulmonary clearance rate of aerosolized {sup 99m}Tc-labeled diethylenetriaminepentaacetate ({sup 99m}Tc-DTPA) and pulmonary mechanics were studied in seven healthy nonsmoking volunteers. {sup 99m}Tc-DTPA clearance and pulmonary mechanics (lung volumes and compliance) were assessed before and after 75 min of constant-load exercise performed on a treadmill, corresponding to 75% of maximal O{sub 2} uptake. Because both clearance measurements were made in similar conditions of pulmonary blood flow, respiratory rate, and tidal volume, changes in clearance rate can be assumed to represent changes of alveolar epithelial permeability. After exercise, total, apical, and basal clearance were significantly increased (P less than 0.01, 0.05, and 0.05, respectively) and the increases in total clearance and tidal volume observed during exercise were significantly correlated (P less than 0.05). In contrast, no significant change was found in pulmonary mechanics. These results show that prolonged intensive exercise induces an increase in epithelial permeability, which appears to be related to the mechanical effects of sustained increased ventilation. Because no change was evidenced in pulmonary volumes or in lung elasticity, our results suggest that this increase may result from alteration of the intercellular tight junctions rather than from a surfactant deficiency.

• OSTI ID: 7105242
• Journal Information: Journal of Applied Physiology (1985); (USA), Vol. 67:5; ISSN 8750-7587
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DTPA
LUNG CLEARANCE
EPITHELIUM
PERMEABILITY
EXERCISE
BIOLOGICAL EFFECTS
LUNGS
PHYSIOLOGY
AEROSOLS
ISOMERIC NUCLEI
MAN
OXYGEN
RESPIRATION
TECHNETIUM 99
TRACER TECHNIQUES
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
DISPERSIONS
DRUGS
ELEMENTS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SOLS
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques