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Title: Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation

Abstract

The treatment of female (New Zealand black x New Zealand white)F1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation-treated mice also showed a marked reduction of Ly-1 B cells, which lasted up to 3 months. The subsequent return of Ly-1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti-DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly-1- (CD5-) splenic B cell population.

Authors:
; ; ; ; ;  [1]
  1. Stanford Univ. School of Medicine, CA (USA)
Publication Date:
OSTI Identifier:
7099676
Resource Type:
Journal Article
Journal Name:
Arthritis and Rheumatism; (USA)
Additional Journal Information:
Journal Volume: 33:4; Journal ID: ISSN 0004-3591
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; IMMUNE SYSTEM DISEASES; RADIOTHERAPY; LYMPHATIC SYSTEM; IRRADIATION; LYMPHOCYTES; BIOLOGICAL RADIATION EFFECTS; DNA; INHIBITION; LYMPH NODES; MICE; SPLEEN; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; LEUKOCYTES; MAMMALS; MATERIALS; MEDICINE; NUCLEAR MEDICINE; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIOLOGY; RODENTS; SOMATIC CELLS; THERAPY; VERTEBRATES; 550603* - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Farinas, M C, Stall, A M, Solovera, J J, Tarlinton, D M, Herzenberg, L A, and Strober, S. Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation. United States: N. p., 1990. Web. doi:10.1002/art.1780330413.
Farinas, M C, Stall, A M, Solovera, J J, Tarlinton, D M, Herzenberg, L A, & Strober, S. Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation. United States. https://doi.org/10.1002/art.1780330413
Farinas, M C, Stall, A M, Solovera, J J, Tarlinton, D M, Herzenberg, L A, and Strober, S. 1990. "Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation". United States. https://doi.org/10.1002/art.1780330413.
@article{osti_7099676,
title = {Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation},
author = {Farinas, M C and Stall, A M and Solovera, J J and Tarlinton, D M and Herzenberg, L A and Strober, S},
abstractNote = {The treatment of female (New Zealand black x New Zealand white)F1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation-treated mice also showed a marked reduction of Ly-1 B cells, which lasted up to 3 months. The subsequent return of Ly-1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti-DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly-1- (CD5-) splenic B cell population.},
doi = {10.1002/art.1780330413},
url = {https://www.osti.gov/biblio/7099676}, journal = {Arthritis and Rheumatism; (USA)},
issn = {0004-3591},
number = ,
volume = 33:4,
place = {United States},
year = {Sun Apr 01 00:00:00 EST 1990},
month = {Sun Apr 01 00:00:00 EST 1990}
}