Induction of mammary tumors in aging rats by 7,12-dimethylbenz(a)anthracene: role of DNA synthesis during carcinogenesis
- Roswell Park Memorial Inst., Buffalo, NY
Two routes of administration were used to test the susceptibility of the mammary gland of the rat to 7,12-dimethylbenz(a)anthracene (DMBA) carcinogenesis in relation to age of the tissue. In one series of experiments, 60-, 70-, 90-, 120-, 150-, and 200-day-old female nonbred Sprague-Dawley rats were given DMBA iv. In parallel experiments, rats of the same ages as those above were given DMBA by local application. Mammary tumors developed in 89 to 90% of the 60- and 70-day-old rats and in 40% of the 90-day-old rats. Rats 120 days old and older were completely refractory to DMBA. In contrast, all rats, irrespective of their ages, developed tumors when DMBA was applied locally. DMBA given iv significantly inhibited DNA synthesis in mammary glands, but DMBA applied locally significantly increased the Li of the mammary glands.
- OSTI ID:
- 7097103
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 64:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOGENESIS
AGE DEPENDENCE
DIMETHYLBENZANTHRACENE
BIOLOGICAL EFFECTS
INJECTION
COMPARATIVE EVALUATIONS
INTRAVENOUS INJECTION
MAMMARY GLANDS
AUTORADIOGRAPHY
DNA
DNA REPLICATION
NEOPLASMS
RATS
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
DISEASES
GLANDS
INTAKE
MAMMALS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)