Evaluation of treatment response to radiotherapy in head and neck cancer with fluorine-18 fluorodeoxyglucose

Journal Article · Thu Sep 01 00:00:00 EDT 1988 · J. Nucl. Med.; (United States)

OSTI ID:7095094

Minn, H; Paul, R; Ahonen, A

Nineteen patients with malignant head and neck tumors were imaged before and during radiation therapy with /sup 18/F-2-fluoro-2-deoxy-D-glucose (FDG) to study the effect of radiotherapy (RT) on FDG uptake. All tumor images were FDG-positive before treatment. After RT, a decrement of tumor FDG uptake was found in all but two patients; these were nonradioresponders. There was a significant decrement (p less than 0.001) in uptake ratios after irradiation of 30 +/- 5 Gy among the radioresponsive (CR + PR) but not among the radioresistant (NC + PD) tumors. The administered dose of RT correlated (r = 0.47, p less than 0.05) with the decrement in FDG activity among the CR + PR but not among the NC + PD patients. The biologic half-life of FDG radioactivity in tumor tissue was evaluated by dynamic scintigraphy. A change in the half-life of FDG toward the value observed in normal tissue was associated with treatment response. The results suggest that FDG imaging can be used for follow-up of RT in patients with head and neck cancer.

• Research Organization: Univ. Central Hospital, Turku (Finland)
• OSTI ID: 7095094
• Journal Information: J. Nucl. Med.; (United States), Vol. 29:9
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
FLUORODEOXYGLUCOSE
UPTAKE
HEAD
NEOPLASMS
NECK
DIAGNOSIS
BIOLOGICAL HALF-LIFE
FLUORINE 18
PATIENTS
SCINTISCANNING
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BODY AREAS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics