Fluorine-18-N-methylspiroperidol: radiolytic decomposition as a consequence of high specific activity and high dose levels

Journal Article · Thu Jan 01 00:00:00 EST 1987 · J. Nucl. Med.; (United States)

OSTI ID:7093776

MacGregor, R R; Schlyer, D J; Fowler, J S; Wolf, A P; Shiue, C Y

High specific activity (/sup 18/F)N-methylspiroperidol(8-(4-(4-(18F)fluorophenyl)-4-oxobutyl)-3-me thyl l-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one, 5-10 mCi/ml, 4-8 Ci/mumol at EOB) in saline solution undergoes significant radiolytic decomposition resulting in a decrease in radiochemical purity of 10-25% during the first hour. The rate of decomposition is affected by the specific activity, total dose to and chemical composition of the solution. That radiolysis is responsible for the observed decomposition was verified by the observation that unlabeled N-methylspiroperidol is decomposed in the presence of (18F)fluoride.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 7093776
• Journal Information: J. Nucl. Med.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
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EMISSION COMPUTED TOMOGRAPHY
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QUALITY CONTROL
RADIOCHEMISTRY
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BETA DECAY RADIOISOTOPES
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MIXTURES
NUCLEI
ODD-ODD NUCLEI
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