Radioautographic investigation of retinal growth in mature amphibians

Journal Article · Tue Jul 01 00:00:00 EDT 1986 · Sov. J. Dev. Biol. (Engl. Transl.); (United States)

OSTI ID:7092337

Svistunov, S A; Mitashov, V I

Growth of the retina was studied in mature intact amphibians, tritons, axolotls, ambystomas and clawed frogs, for six months using multiple injection of /sup 3/H-thymidine. It was established that the source of replenishment of the retina by new cells is its terminal zone in all animals investigated. This is attested to by the gradual migration of labeled cells from the growth zone into differentiated layers of the retina. The most intensely labeled cells occupy a distal position relative to other labeled cells, therefore marking the boundary between the initial part of the retina, not containing labeled nuclei, and the part being augmented. For each species studied, a level of proliferative activity is characteristic for cells of the terminal zone, which decreases in the order axolotl-clawed frog-triton -ambystoma. In the axolotl and additional growth zone is noted in the retina, in addition to the terminal, which is located in the area of the unclosed section of the embryonic fissure. Results obtained serve as a basis for the regenerative potentials of eye tissues revealed previously in these amphibian species.

• Research Organization: N.K. Kol'stov Institute of Developmental Biology, Acad. of Sci.
• OSTI ID: 7092337
• Journal Information: Sov. J. Dev. Biol. (Engl. Transl.); (United States), Vol. 16:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AMPHIBIANS
RETINA
AUTORADIOGRAPHY
CELL PROLIFERATION
GROWTH
ANIMAL CELLS
BIOLOGICAL REGENERATION
LABELLING
METABOLISM
RADIONUCLIDE KINETICS
THYMIDINE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
AQUATIC ORGANISMS
AZINES
BIOLOGICAL RECOVERY
BODY
BODY AREAS
DISTRIBUTION
EYES
FACE
HEAD
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RECOVERY
RIBOSIDES
SENSE ORGANS
VERTEBRATES
550301* - Cytology- Tracer Techniques