Respiratory-tract dosimetry of /sup 18/O-labeled ozone in rats: implications for a rat-human extrapolation of ozone dose

Technical Report · Mon Aug 01 00:00:00 EDT 1988

OSTI ID:7090836

Hatch, G E; Wiester, M J; Overton, J H; Aissa, M

Efforts to obtain a comparison between rats and humans of the dose of inhaled ozone (O/sub 3/) delivered to the lungs during O/sub 3/ exposure has been impeded because of the lack of data on the nasopharyngeal removal of O/sub 3/ in rats. This study sought to address the need through use of a newly developed tracing technique that involved oxygen-18 labeled O/sub 3/. Comparison of the result to a published value of about 40% nasopharyngeal removal in the resting human, yields the conclusion that the O/sub 3/ concentration in the rat trachea is about 30% higher than in the human trachea under similar exposure conditions.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 7090836
• Report Number(s): PB-88-239017/XAB; EPA-600/D-88/174
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
54 ENVIRONMENTAL SCIENCES
OXYGEN 18
TRACER TECHNIQUES
OZONE
RESPIRATION
RESPIRATORY SYSTEM
AIR POLLUTION
COMPARATIVE EVALUATIONS
DOSIMETRY
MAN
RATS
TISSUE DISTRIBUTION
TRACHEA
ANIMALS
DISTRIBUTION
EVEN-EVEN NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
NUCLEI
OXYGEN ISOTOPES
POLLUTION
PRIMATES
RODENTS
STABLE ISOTOPES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)