Effect of 3-methylcholanthrene-induced increases in ascorbic acid levels on tissue. beta. -glucuronidase activity in rats

Journal Article · Fri Jan 01 00:00:00 EST 1988 · J. Environ. Sci. Health, Part A; (United States)

DOI:https://doi.org/10.1080/10934528809375389· OSTI ID:7090454

Calabrese, E J; Barrett, T J; Leonard, D A; Horton, H M; Kenyon, E M

The interrelationship between tissue ascorbic acid levels and tissue ..beta..-glucuronidase activity was examined in rats injected with 3-methylcholanthrene, an agent which induces ascorbic acid synthesis in rats. Six Fisher 344 rats were dosed intraperitoneally (IP) with 30 mg/kg of 3-methylcholanthrene. Ascorbic acid levels and ..beta..-glucuronidase (..beta..-G) activity were determined for lung, liver and kidney tissues. In a follow-up study, rats were dosed for three consecutive days with 3-methylcholanthrene. Controls in both groups were dosed IP with Emulphor (EL-620). Animals were sacrificed one week after the final dosage and lung, liver and kidney tissues were examined.

• Research Organization: Univ. of Massachusetts, Amherst (USA)
• OSTI ID: 7090454
• Journal Information: J. Environ. Sci. Health, Part A; (United States), Vol. A23:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
3-METHYLCHOLANTHRENE
BIOLOGICAL EFFECTS
ASCORBIC ACID
BIOCHEMICAL REACTION KINETICS
GLUCURONIDASE
EXTRAPOLATION
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
LUNGS
RATS
ANIMALS
AROMATICS
BODY
DIGESTIVE SYSTEM
ENZYMES
GLANDS
GLYCOSYL HYDROLASES
HYDROCARBONS
HYDROLASES
INJECTION
INTAKE
KINETICS
MAMMALS
NUMERICAL SOLUTION
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
POLYCYCLIC AROMATIC HYDROCARBONS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
VITAMINS
560300* - Chemicals Metabolism & Toxicology
550200 - Biochemistry