Comparison of three tests for estimating gastroenteral protein loss

Conference · Sun Jan 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:7089160

Glaubitti, D; Marx, M; Weller, H

A decisive step in the diagnosis of exudative gastroenteropathy which shows a pathologically increased transfer of plasma proteins into the stomach or intestine is the measurement of fecal radioactivity after intravenous administration of radionuclide-labeled large organic compounds or of small inorganic compounds attaching themselves to plasma proteins within the patient. In 24 patients (12 men and women each) aged 40 to 66 years, the gastroenteral protein loss was estimated after intravenous injection of Cr-51 chloride, Cr-51 human serum albumin, or Fe-59 iron dextran. Each test lasted 6 days. There was an interval of 2 weeks between 2 tests. The feces were collected completely within the test period for determination of radioactivity. External probe counting over liver, spleen, right kidney, and thyroid was performed daily up to 10 days. The results obtained with Cr-51 chloride presented the largest range whereas the test with Fe-59 iron dextran exhibited both the smallest deviation from the mean value and the lowest normal range. During the tests for gastroenteral protein loss external probe counting demonstrated no distinct tendency to a more rapid radionuclide loss from liver, spleen, and kidney in the patients suffering from exudative gastroenteropathy when compared with healthy subjects. The authors conclude that the most suitable test to estimate gastroenteral protein loss is the Fe-59 iron dextran test although Fe-59 iron dextran is not available commercially and causes a higher radiation burden than the other tests do. In second place, the Cr-51 chloride test should be used, the radiopharmaceutical of which is less expensive and has no significant disadvantage in comparison with Cr-51 human serum albumin.

• Research Organization: Dept. of Nuclear Medicine, Academic Teaching Hospital, Krefeld
• OSTI ID: 7089160
• Report Number(s): CONF-840619-
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
DIAGNOSTIC USES
LABELLING
LOSSES
CHLORIDES
CHROMIUM 51
TRACER TECHNIQUES
DEXTRAN
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
INTESTINES
RADIOISOTOPE SCANNING
IRON 59
STOMACH
EXCRETION
FECES
PATHOLOGY
RADIOACTIVITY
TESTING
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SUBSTITUTES
BODY
CARBOHYDRATES
CHLORINE COMPOUNDS
CHROMIUM ISOTOPES
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
HALIDES
HALOGEN COMPOUNDS
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
PROTEINS
RADIOISOTOPES
SACCHARIDES
USES
WASTES
550601* - Medicine- Unsealed Radionuclides in Diagnostics