Breath /sup 14/CO2 after intravenous administration of (/sup 14/C)aminopyrine in liver diseases

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01308121· OSTI ID:7089107

Pauwels, S; Geubel, A P; Dive, C; Beckers, C

The determination of of /sup 14/CO2 in breath after oral administration of (/sup 14/C)aminopyrine has been proposed as a quantitative liver function test. In order to shorten the procedure and avoid misinterpretations related to variable rates of intestinal absorption, the (/sup 14/C)aminopyrine breath test (ABT) was performed after intravenous administration of (/sup 14/C)aminopyrine in 21 controls and 89 patients with biopsy-proven liver disease. The specific activity of the first hour sample corrected for body weight (SA1) was the most discriminant expression of breath data. The SA1 value, expressed as the percentage of the administered dose, was 0.86 +/- 0.1% (mean +/- SD) in controls and significantly less in patients (0.46 +/- 0.31%). Low values were observed in patients with untreated chronic active hepatitis (0.16 +/- 0.13%), alcoholic cirrhosis (0.2 +/ 0.15%0, and untreated postnecrotic cirrhosis (0.47 +/- 0.17%). In contrast, normal values were obtained in chronic persistent hepatitis (0.86 +/- 0.13%) and 58% of noncirrhotic alcoholic liver diseases (0.83 +/- 0.27%). The results of duplicate studies were reproducible and SA1 correlated with other conventional liver function tests, including 45-min BSP retention. Among these, ABT was the most sensitive screening test for the presence of cirrhosis, especially in alcoholic patients, where it allowed a sharp distinction between cirrhotic and noncirrhotic cases. The results obtained in chronic hepatitis suggested that ABT may provide a reliable index of the activity of the disease. In our hands, intravenous ABT, performed over a 1-hr period, was a fast, sensitive, and discriminant liver function test.

• Research Organization: Department of Nuclear Medicine, University of Louvain Medical School, Brussels, Belgium
• OSTI ID: 7089107
• Journal Information: Dig. Dis. Sci.; (United States), Vol. 27:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
BREATH
QUANTITATIVE CHEMICAL ANALYSIS
CARBON 14 COMPOUNDS
ISOTOPE APPLICATIONS
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
BIOPSY
CARBON DIOXIDE
COMPARATIVE EVALUATIONS
EXCRETION
LIVER
PATIENTS
STATISTICS
TIME DEPENDENCE
TRACER TECHNIQUES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
CHEMICAL ANALYSIS
CLEARANCE
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GLANDS
LABELLED COMPOUNDS
MATHEMATICS
ORGANS
OXIDES
OXYGEN COMPOUNDS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques