Single-photon tomographic determination of regional cerebral blood flow in psychiatric disorders

Conference · Sun Jan 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:7087558

Devous, Sr, M D; Rush, A J; Schlesser, M A; Debus, J; Raese, J D; Chehabi, H H; Bonte, F J

Regional cerebral blood flow (rCBF) was measured by single-photon emission computed tomography (SPECT) of 133-Xe washout in 29 normal volunteers, 22 unipolar endogenous depressives (UPE), 9 unipolar nonendogenous depressives (UPNE), 13 bipolar depressed patients (BPD), and 14 schizophrenic patients (SCHZ). RCBF was measured 2 and 6 cm above and parallel to the cantho-meatal line and quantitated in 14 gray matter regions. Most subjects were drug-free for 4-14 days. Diagnoses were made by experienced clinicians employing the Research Diagnostic Criteria, the Hamilton Rating Scale, and the dexamethasone suppression test. SCHZ were rated with the Brief Psychiatric Rating Scale. UPE had reduced flow compared to normals in the right parietal and temporal lobes and a nonsignificant trend toward left temporal flow reductions. UPNE were not different from normal or other patient groups. BPD had significant flow elevations in the left hemisphere relative to normal, and in both hemispheres relative to UPE. SCHZ were not significantly different from normal or other patient groups. Anterior-posterior flow shifts were evaluated by subtracting parietal or temporal flows from frontal flows. SCHZ demonstrated a greater posterior shift (lower relative frontal lobe flow) in comparison to both UPE and UPNE. The most significant regional flow abnormalities were observed as frontal flow reductions in individual SCHZ, although these were not significant in the whole group in comparison to normal.

• Research Organization: Univ. of Texas Health Science Center, Dallas, TX
• OSTI ID: 7087558
• Report Number(s): CONF-840619-
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
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DIAGNOSTIC USES
COMPARATIVE EVALUATIONS
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HYDROXY COMPOUNDS
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ORGANIC COMPOUNDS
ORGANS
PREGNANES
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