Effects of large (0. 9. mu. m) sulfuric acid aerosols on human pulmonary function
The effects of sulfuric acid particle concentration (mass/volume) and ambient temperatures on pulmonary function of young male nonsmokers were examined. Subjects (n = 11) thrice repeated a sequence of 20-min exercise (ventilation approximately 30 liters/min) and 20-min sitting rest. Pre- and postexposure pulmonary function tests (forced vital capacity maneuvers, lung volumes, maximum voluntary ventilation, R/sub aw/, TGV, and helium-oxygen FVC) were measured. During the exposure and at 2 min after cessation of each exercise period, forced vital capacity tests (air and helium-oxygen) were performed. Each subject was exposed in random order to filtered air or 233, 418, or 939 ..mu..g/m/sub 3/ particulate sulfuric acid. Mass median diameter (MMD) was 0.90-0.93 ..mu..m, and geometric SD was 1.66-1.73. No major changes in pulmonary function related to sulfate were observed in these subjects. The only measurement to show a significant interaction across time (pre-post) and sulfate concentration was FEV /sub 1.0/, which was significantly decreased with exposure to 939 ..mu..g/m/sup 3/ sulfate. The magnitude of the decrease was not considered to be of physiological significance. These results indicate that, even with the added stress of the increased depth and volume of exercise ventilation, exposure to as much as 1 mg/m/sup 3/ of 1 ..mu.. for ..mu..m sulfuric acid aerosol for 2 hr has little if any effect on standard tests of lung function.
- Research Organization:
- Univ. of California, Santa Barbara
- OSTI ID:
- 7083737
- Journal Information:
- Environ. Res.; (United States), Vol. 28:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
LUNGS
DYNAMIC FUNCTION STUDIES
SULFURIC ACID
BIOLOGICAL EFFECTS
AEROSOLS
PARTICLE SIZE
PATIENTS
BODY
COLLOIDS
DISPERSIONS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
ORGANS
RESPIRATORY SYSTEM
SIZE
SOLS
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
551000 - Physiological Systems