Behavioral and histological effects of acrylamide in rainbow trout

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(87)90095-0· OSTI ID:7081851

Petersen, D W; Cooper, K R; Friedman, M A; Lech, J J

A histological and behavioral study was used to assess whether acrylamide produced neurotoxic effects in rainbow trout. Swimming performance of trout exposed to 0, 12.5, or 25 mg/liter acrylamide for 15 days was unaffected. Swimming performance of animals exposed to 50 mg/liter acrylamide for a similar time period was compromised by morbidity and mortality of the animals in this treatment group. The absence of dose-related histological lesions in central neurons, peripheral neurons or muscle suggested that the observed deficit in swimming performance was due to a generalized toxic response. Acrylamide treatment produced dose-related lesions in the gill and liver of rainbow trout.

• Research Organization: Medical College of Wisconsin, Milwaukee
• OSTI ID: 7081851
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLAMIDE
TOXICITY
TROUT
BEHAVIOR
DOSE-RESPONSE RELATIONSHIPS
GILLS
LIVER
NERVOUS SYSTEM
WATER POLLUTION
AMIDES
ANIMALS
AQUATIC ORGANISMS
BODY
DIGESTIVE SYSTEM
FISHES
GLANDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
POLLUTION
RESPIRATORY SYSTEM
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology