Separation of carrier-free holmium-166 from neutron-irradiated dysprosium targets
- ANSTO, Menai, New South Wales (Australia)
- Oak Ridge National Lab., TN (United States)
Holmium-166 ([sup 166]Ho, t[sub 1/2] = 26.4 h) is utilized in radiotherapeutic applications such as radioimmunospecific pharmaceuticals, bone marrow ablation, and radiation synovectomy. High specific activity [sup 166]Ho can be obtained from the decay of dysprosium-166 ([sup 166]Dy, t[sub 1/2] = 81.5 h). Dysprosium-166 is produced by the [sup 164]Dy[n,[gamma]][sup 165]Dy[n,[gamma]][sup 166]Dy reaction in a nuclear reactor. The applicability of reversed phase ion-exchange chromatographic methods was demonstrated for the separation of carrier-free [sup 166]Ho from milligram quantities of [sup 164]Dy[sub 2]O[sub 3] irradiated targets. An efficient and quantitative separation was achieved utilizing a metal-free HPLC system with Dowex AG 50WX12 or Aminex-A5 cation exchangers and [alpha]-hydroxy-isobutyric acid ([alpha]-HIBA) as the eluent (0.085 M, pH = 4.3 adjusted with NH[sub 4]OH). The Aminex-A5 column gave a separation factor of approximately 10[sup 3] between Ho and Dy. Subsequent to the acidic destruction of the Ho-HIBA complex, Ho[sup 3+] was further purified on a small cation-exchange column from acidic chloride solutions. The separation was achieved within 2 h, with a 95% overall radiochemical yield for carrier-free [sup 166]Ho with a Dy breakthrough of < 0.1%. 32 refs., 7 figs., 1 tab.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 7079364
- Journal Information:
- Analytical Chemistry (Washington); (United States), Vol. 66:23; ISSN 0003-2700
- Country of Publication:
- United States
- Language:
- English
Similar Records
Nuclear Medicine Program progress report for quarter ending June 30, 1992
Development of the Dy-166/Ho-166 in-vivo generator for radionuclide radiotherapy
Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
DYSPROSIUM OXIDES
LIQUID COLUMN CHROMATOGRAPHY
HOLMIUM 166
DYSPROSIUM 164 TARGET
DYSPROSIUM 166
HFIR REACTOR
HIFAR REACTOR
HOLMIUM COMPLEXES
ION EXCHANGE MATERIALS
NEUTRONS
RADIOTHERAPY
SPECTROPHOTOMETRY
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
CHROMATOGRAPHY
COMPLEXES
DAYS LIVING RADIOISOTOPES
DYSPROSIUM COMPOUNDS
DYSPROSIUM ISOTOPES
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
EVEN-EVEN NUCLEI
FERMIONS
HADRONS
HEAVY WATER COOLED REACTORS
HEAVY WATER MODERATED REACTORS
HOLMIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION REACTORS
ISOTOPES
MATERIALS
MATERIALS TESTING REACTORS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIOLOGY
RARE EARTH COMPLEXES
RARE EARTH COMPOUNDS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
SECONDS LIVING RADIO
SEPARATION PROCESSES
TANK TYPE REACTORS
TARGETS
TEST REACTORS
THERAPY
THERMAL
THERMAL REACTORS
WATER COOLED REACTORS
WATER MODERATED REACTORS
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
400102 - Chemical & Spectral Procedures
550603 - Medicine- External Radiation in Therapy- (1980-)