Structure and chromosomal localization of the gene encoding the human myelin protein zero (MPZ)

Journal Article · Wed Sep 01 00:00:00 EDT 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1400· OSTI ID:7076084

Hayasaka, Kiyoshi; Himoro, Masato; Takada, Goro ^[1]; Wang, Yimin; Takata, Mizuho; Minoshima, Shinsei; Shimizu, Nobuyoshi; Miura, Masayuki; Uyemura, Keiichi ^[2]

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1. Akita Univ. School of Medicine, Akita (Japan)
2. Keio Univ. School of Medicine, Tokyo (Japan)

The authors describe the cloning, characterization, and chromosomal mapping of the human myelin protein zero (MPZ) gene (a structural protein of myelin and an adhesive glycoprotein of the immunoglobulin superfamily). The gene is about 7 kb long and consists of six exons corresponding of the functional domains. All exon-intron junction sequences conform to the GT/AG rule. The 5[prime]-flanking region of the gene has a TA-rich element (TATA-like box), two CAAT boxes, and a single defined transcription initiation site detected by the primer extension method. The gene for human MPZ was assigned to chromosome 1q22-q23 by spot blot hybridization of flow-sorted human chromosomes and fluorescence in situ hybridization. The localization of the MPZ gene coincides with the locus for Charcot-Marie-Tooth disease type 1B, determined by linkage analysis. 20 refs., 3 figs., 1 tab.

• OSTI ID: 7076084
• Journal Information: Genomics; (United States), Vol. 17:3; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 1
GENETIC MAPPING
MEMBRANE PROTEINS
GENES
MYELIN
HEREDITARY DISEASES
NERVOUS SYSTEM DISEASES
ETIOLOGY
DNA SEQUENCING
DNA-CLONING
CELL CONSTITUENTS
CELL MEMBRANES
CHROMOSOMES
CLONING
DISEASES
DNA HYBRIDIZATION
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
MEMBRANES
ORGANIC COMPOUNDS
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
550400* - Genetics
550900 - Pathology