Inhibition of platelet (/sup 3/H)- imipramine binding by human plasma protein fractions

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90012-4· OSTI ID:7070062

Strijewski, A; Chudzik, J; Tang, S W

Inhibition of high-affinity (/sup 3/H)-imipramine binding to platelet membranes by human plasma fractions and isolated plasma proteins was investigated. Several plasma proteins were found to contribute to the observed apparent inhibition and this contribution was assessed in terms of inhibitor units. Alpha/sub 1/ acid glycoprotein, high density and low density lipoprotein, IgG and ..cap alpha../sub 1/-antitrypsin were identified as effective non-specific inhibitors. Alpha-1-acid glycoprotein was confirmed to be the most potent plasma protein inhibitor. Cohn fractions were evaluated for the presence of the postulated endocoid of (/sup 3/H)-imipramine binding site.

• Research Organization: Clarke Institute of Psychiatry, Toronto, Ontario (Canada)
• OSTI ID: 7070062
• Journal Information: Life Sci.; (United States), Vol. 42:16
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIDEPRESSANTS
BIOCHEMICAL REACTION KINETICS
RECEPTORS
GLUCOPROTEINS
BIOLOGICAL FUNCTIONS
BLOOD PLASMA
BLOOD PLATELETS
INHIBITION
MAN
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
FUNCTIONS
GLYCOPROTEINS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
PSYCHOTROPIC DRUGS
REACTION KINETICS
SACCHARIDES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques