Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats
Gossypol-acetic acid (GAA) has been shown to be a powerful chelator of iron. To determine how subchronic administration of GAA affects the distribution and utilization of radioiron, male Holtzman rats, which had received a daily oral dose of GAA (20 mg/kg body weight) for 16 weeks, were injected i.p. with (/sup 59/Fe)citrate (activity = 16.5 muCi/kg body weight) and (/sup 59/Fe) incorporation into circulating erythrocytes, bone marrow, liver, spleen, skeletal muscle, and urine was measured 6, 12, or 24 h after (/sup 59/Fe) administration. Iron (/sup 59/Fe) incorporation was enhanced in the spleens, livers, bone marrow, and blood of the GAA-treated rats, and increased as the time post-(/sup 59/Fe) injection increased. Hematological parameters remained within normal limits throughout the 16-week treatment period, suggesting an erythropoietic compensation in the GAA-treated rats. Iron status was markedly different in the GAA-treated rats at the end of the 16 week treatment period, suggesting altered iron utilization. The data suggest that (/sup 59/Fe) is preferentially distributed to the erythroid tissues of GAA-treated rats for utilization in erythropoiesis.
- Research Organization:
- Illinois State Univ., Normal (USA)
- OSTI ID:
- 7069882
- Journal Information:
- Drug Chem. Toxicol.; (United States), Vol. 11:2
- Country of Publication:
- United States
- Language:
- English
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Radioiron utilization and gossypol acetic acid in male rats
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59 BASIC BIOLOGICAL SCIENCES
ACETIC ACID
BIOLOGICAL EFFECTS
IRON
TISSUE DISTRIBUTION
BONE MARROW
ERYTHROCYTES
IRON 59
LIVER
METABOLISM
ORAL ADMINISTRATION
RATS
SPLEEN
TRACER TECHNIQUES
ANIMAL TISSUES
ANIMALS
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BODY
BODY FLUIDS
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
METALS
MONOCARBOXYLIC ACIDS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
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