Intracranial tumors: response and resistance to therapeutic endeavors, 1970-1980

Journal Article · Thu Jul 01 00:00:00 EDT 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90056-6· OSTI ID:7069183

Bloom, H J.G.

The response and resistance of various kinds of intracranial tumors to radiotherapy and chemotherapy is discussed. Such tumors as germinomas in the pineal and suprasellar regions are very radiosensitive and highly curable. Medulloblastomas are also very radiosensitive, but the presence of local residual resistant tumor has restricted cure rates to approximately 40%. High grade astrocytomas remain resistant to radiotherapy and virtually incurable. Inoperable deep gliomas vary widely in the response to irradiation. In addition to tumor response to treatment, consideration must also be given to reaction of normal tissue to irradiation, to chemotherapy, and to a combination of these modalities: these may produce late effects leading to disturbance of neurological and endocrine function and of intellectual and emotion disorders. (JMT)

• Research Organization: Royal Marsden Hospital, London, England
• OSTI ID: 7069183
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:7
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
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550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man