Imaging of inflammatory arthritis with technetium-99m-labeled IgG

Journal Article · Fri Dec 01 00:00:00 EST 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:7068367

Breedveld, F C; van Kroonenburgh, M J; Camps, J A; Feitsma, H I; Markusse, H M; Pauwels, E K ^[1]

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1. University Hospital, Leiden (Netherlands)

The accumulation of nonspecific polyclonal human immunoglobulin G (IgG) radiolabeled with 99mTc was compared to that of (99mTc)albumin and (99mTc)nanocolloid in rats with collagen induced arthritis. Serial scintigrams were acquired directly, 4 and 24 hr after injection. A clearly discernable image of the site of synovitis was seen with (99mTc)IgG as early as 4 hr postinjection. The relative intensity of the inflammatory lesion was maximal at 24 hr. Discrimination between arthritic and nonarthritic joints as well as correlations between the relative intensity of the arthritic joint and clinical indices of joint inflammation were superior with IgG compared to albumin or nanocolloid. These studies show that localization and severity of inflammatory joint disease can be detected with radiolabeled nonspecific IgG.

• OSTI ID: 7068367
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 30:12; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IMMUNOGLOBULINS
BIOLOGICAL LOCALIZATION
RHEUMATIC DISEASES
DIAGNOSIS
ALBUMINS
COLLAGEN
ISOMERIC NUCLEI
MAN
RATS
SCINTISCANNING
TECHNETIUM 99
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
GLOBULINS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SCLEROPROTEINS
SKELETAL DISEASES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics