Reductions in (/sup 3/H)nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study

Journal Article · Sun May 01 00:00:00 EDT 1988 · Neurology; (United States)

OSTI ID:7067845

Whitehouse, P J; Martino, A M; Wagster, M V; Price, D L; Mayeux, R; Atack, J R; Kellar, K J

In Alzheimer's disease (AD) and Parkinson's disease (PD), dysfunction in the basal forebrain cholinergic system is accompanied by a consistent loss of presynaptic cholinergic markers in cortex, but changes in cholinergic receptor binding sites are poorly understood. In the present study, we used receptor autoradiography to map the distribution of nicotinic (/sup 3/H)acetylcholine binding sites in cortices of individuals with AD and PD and matched control subjects. In both diseases, a profound loss of nicotinic receptors occurs in all cortical layers, particularly the deepest layers.

• Research Organization: Case Western Reserve Univ., Cleveland, OH (USA)
• OSTI ID: 7067845
• Journal Information: Neurology; (United States), Vol. 38:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ACETYLCHOLINE
BIOCHEMICAL REACTION KINETICS
RECEPTORS
NERVOUS SYSTEM DISEASES
PATHOGENESIS
AUTORADIOGRAPHY
CEREBRAL CORTEX
TRITIUM COMPOUNDS
AMINES
AMMONIUM COMPOUNDS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
DISEASES
DRUGS
ESTERS
KINETICS
LABELLED COMPOUNDS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PROTEINS
QUATERNARY COMPOUNDS
REACTION KINETICS
550901* - Pathology- Tracer Techniques