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Title: In-111-labeled white blood cell uptake in noninfected closed fracture in humans: prospective study

Abstract

Since indium-111 white blood cell (In-111 WBC) scintigraphy is often used to evaluate for osteomyelitis in bone fractures, it is important to know if noninfected fractures have In-111 WBC uptake. Twenty-seven noninfected closed fracture sites in 19 patients were prospectively evaluated with technetium-99m methylene diphosphonate bone scintigraphy and In-111 WBC scintigraphy. In-111 WBC uptake was present in 41% of the 27 sites. In the 11 positive sites, the In-111 WBC uptake was 1+ (definite but minimal) in 55%, 2+ (moderate) in 36%, and 3+ (marked) in 9%. The visual intensity of the radioactive uptake on In-111 WBC scintigrams relative to that on bone scintigrams was less in 82%, equal in 9%, and greater in 9%. The visual size of the area of uptake on In-111 WBC scintigrams and bone scintigrams was smaller in 36%, equal in 55%, and greater in 9%. Factors that may help distinction of In-111 WBC uptake due to fracture alone from infection associated with fracture are discussed.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Uniformed Services Univ. of Health Sciences, Washington, DC (USA)
OSTI Identifier:
7066974
Resource Type:
Journal Article
Journal Name:
Radiology; (United States)
Additional Journal Information:
Journal Volume: 167:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; INDIUM 111; UPTAKE; LEUKOCYTES; SCINTISCANNING; SKELETON; RADIONUCLIDE KINETICS; BONE FRACTURES; ISOMERIC NUCLEI; MAN; OSTEOMYELITIS; PATIENTS; TECHNETIUM 99; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INDIUM ISOTOPES; INJURIES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRIMATES; RADIOISOTOPE SCANNING; RADIOISOTOPES; SKELETAL DISEASES; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Van Nostrand, D, Abreu, S H, Callaghan, J J, Atkins, F B, Stoops, H C, and Savory, C G. In-111-labeled white blood cell uptake in noninfected closed fracture in humans: prospective study. United States: N. p., 1988. Web. doi:10.1148/radiology.167.2.3357961.
Van Nostrand, D, Abreu, S H, Callaghan, J J, Atkins, F B, Stoops, H C, & Savory, C G. In-111-labeled white blood cell uptake in noninfected closed fracture in humans: prospective study. United States. https://doi.org/10.1148/radiology.167.2.3357961
Van Nostrand, D, Abreu, S H, Callaghan, J J, Atkins, F B, Stoops, H C, and Savory, C G. 1988. "In-111-labeled white blood cell uptake in noninfected closed fracture in humans: prospective study". United States. https://doi.org/10.1148/radiology.167.2.3357961.
@article{osti_7066974,
title = {In-111-labeled white blood cell uptake in noninfected closed fracture in humans: prospective study},
author = {Van Nostrand, D and Abreu, S H and Callaghan, J J and Atkins, F B and Stoops, H C and Savory, C G},
abstractNote = {Since indium-111 white blood cell (In-111 WBC) scintigraphy is often used to evaluate for osteomyelitis in bone fractures, it is important to know if noninfected fractures have In-111 WBC uptake. Twenty-seven noninfected closed fracture sites in 19 patients were prospectively evaluated with technetium-99m methylene diphosphonate bone scintigraphy and In-111 WBC scintigraphy. In-111 WBC uptake was present in 41% of the 27 sites. In the 11 positive sites, the In-111 WBC uptake was 1+ (definite but minimal) in 55%, 2+ (moderate) in 36%, and 3+ (marked) in 9%. The visual intensity of the radioactive uptake on In-111 WBC scintigrams relative to that on bone scintigrams was less in 82%, equal in 9%, and greater in 9%. The visual size of the area of uptake on In-111 WBC scintigrams and bone scintigrams was smaller in 36%, equal in 55%, and greater in 9%. Factors that may help distinction of In-111 WBC uptake due to fracture alone from infection associated with fracture are discussed.},
doi = {10.1148/radiology.167.2.3357961},
url = {https://www.osti.gov/biblio/7066974}, journal = {Radiology; (United States)},
number = ,
volume = 167:2,
place = {United States},
year = {Sun May 01 00:00:00 EDT 1988},
month = {Sun May 01 00:00:00 EDT 1988}
}