Localized beta dosimetry of sup 131 I -labeled antibodies in follicular lymphoma

Journal Article · Wed Jan 01 00:00:00 EST 1992 · Medical Physics; (United States)

DOI:https://doi.org/10.1118/1.596932· OSTI ID:7066524

Hui, T E; Fisher, D R ^[1]; Press, O W; Eary, J F ^[2]; Weinstein, J N ^[3]; Badger, C C; Bernstein, I D ^[4]

---

1. Health Physics Department, Pacific Northwest Laboratory, Richland, Washington 99352 (United States)
2. University of Washington Medical Center, Seattle, Washington 98195 (United States)
3. National Cancer Institute, Bethesda, Maryland 20892 (United States)
4. Fred Hutchinson Cancer Research Center, Seattle, Washington 98104 (United States)

The purpose of this study is to assess the multicellular dosimetry of {sup 131}I -labeled antibody in follicular lymphoma based on histological measurements on human tumor biopsy tissue. Photomicrographs of lymph node specimens were analyzed by first-order treatment to determine the mean values and statistical variations of the radii of follicles (260{plus minus}90 {mu}m), interfollicular distances (740{plus minus}160 {mu}m), and the number density of follicles (60{plus minus}18 in a volume of (2{times}1480 {mu}m){sup 3}). Based on these measurements, two geometrical models were developed for localized beta dosimetry. The first, a regular cubic lattice model, assumes no variation in follicular radius of follicles and interfollicular distance. The second, a randomized distribution model, is a more complicated but more realistic representation of observed histological specimens. In this model, Monte Carlo methods were used to reconstruct the spatial distribution of follicles by simulating the distribution of the radii of follicles, interfollicular distances, and the number density of follicles. Dose calculations were performed using Berger's point kernels for absorbed-dose distribution for beta particles in water, assuming the {sup 131}I -labeled antibodies as point sources. It was assumed that the activity concentration of the labeled antibody within the follicles was ten times the activity concentration in the interfollicular spaces. The spatial distribution of localized dose was calculated for a tumor having an average dose of 40 Gy. The localized dose was found to be highly nonuniform, ranging from 20 to 90 Gy, and varying by a factor of about 2 from the average tumor dose.

• DOE Contract Number: AC06-76RL01830
• OSTI ID: 7066524
• Journal Information: Medical Physics; (United States), Vol. 19:1; ISSN 0094-2405
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DOSIMETRY
SPATIAL DOSE DISTRIBUTIONS
LYMPHOMAS
ANIMAL TISSUES
ANTIBODIES
BIOPSY
HISTOLOGICAL TECHNIQUES
IODINE 131
LABELLED COMPOUNDS
LYMPH NODES
MONTE CARLO METHOD
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOSIMETRY
IMMUNE SYSTEM DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LYMPHATIC SYSTEM
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIATION DOSE DISTRIBUTIONS
RADIOISOTOPES
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)