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Title: A retrospective study of the effects of pelvic irradiation for carcinoma of the cervix on gastrointestinal function

Abstract

The purpose of the study was to evaluate the prevalence of disordered gastrointestinal function following therapeutic irradiation. Gastrointestinal function was evaluated in 30 randomly selected patients who had received pelvic irradiation for treatment of carcinoma of the cervix between 1 and 6 years previously. Each patient underwent evaluations of (a) gastrointestinal symptoms (b) absorption of bile acid, vitamin B12, lactose and fat (c) gastrointestinal transit: gastric emptying, small intestinal transit and whole gut transit and (d) intestinal permeability. Results were compared with those obtained in 18 normal volunteers. Stool frequency was above the control range in five patients and had increased (p < 0.001) since radiotherapy treatment. Bile acid (p<0.001) vitamin B12(p<0.01) and lactose (p<0.01) absorption were less in the patients when compared with the control subjects. Bile acid adsorption was below the control range in 14 of the 30 patients. Dietary calcium intake was lower (p<0.05) in those patients with lactose malabsorption. Gastric emptying (p<0.01) and small intestinal transit (p<0.01) were more rapid in the patients. Both small intestinal (r=-0.39, p<0.05) and whole gut (r=-0.45) transit were inversely related to stool frequency. Either bowel frequency, bile acid adsorption, vitamin B12 absorption was outside the control range in 19 ofmore » the 30 patients. Abnormal gastrointestinal function is essentially an inevitable long-term sequel of pelvic irradiation. 41 refs., 4 figs., 3 tabs.« less

Authors:
; ; ; ; ;  [1];  [2]
  1. Royal Adelaide Hospital (Australia)
  2. Adelaide Children's Hospital (Australia)
Publication Date:
OSTI Identifier:
7066198
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics; (United States)
Additional Journal Information:
Journal Volume: 26:2; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOMAS; RADIOTHERAPY; GASTROINTESTINAL TRACT; BIOLOGICAL RADIATION EFFECTS; SIDE EFFECTS; UROGENITAL SYSTEM DISEASES; BIOLOGICAL EFFECTS; DIGESTIVE SYSTEM; DISEASES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man

Citation Formats

Yeoh, E, Ahmad, A, Horowitz, M, Russo, A, Muecke, T, Chatterton, B, and Robb, T. A retrospective study of the effects of pelvic irradiation for carcinoma of the cervix on gastrointestinal function. United States: N. p., 1993. Web. doi:10.1016/0360-3016(93)90202-7.
Yeoh, E, Ahmad, A, Horowitz, M, Russo, A, Muecke, T, Chatterton, B, & Robb, T. A retrospective study of the effects of pelvic irradiation for carcinoma of the cervix on gastrointestinal function. United States. https://doi.org/10.1016/0360-3016(93)90202-7
Yeoh, E, Ahmad, A, Horowitz, M, Russo, A, Muecke, T, Chatterton, B, and Robb, T. 1993. "A retrospective study of the effects of pelvic irradiation for carcinoma of the cervix on gastrointestinal function". United States. https://doi.org/10.1016/0360-3016(93)90202-7.
@article{osti_7066198,
title = {A retrospective study of the effects of pelvic irradiation for carcinoma of the cervix on gastrointestinal function},
author = {Yeoh, E and Ahmad, A and Horowitz, M and Russo, A and Muecke, T and Chatterton, B and Robb, T},
abstractNote = {The purpose of the study was to evaluate the prevalence of disordered gastrointestinal function following therapeutic irradiation. Gastrointestinal function was evaluated in 30 randomly selected patients who had received pelvic irradiation for treatment of carcinoma of the cervix between 1 and 6 years previously. Each patient underwent evaluations of (a) gastrointestinal symptoms (b) absorption of bile acid, vitamin B12, lactose and fat (c) gastrointestinal transit: gastric emptying, small intestinal transit and whole gut transit and (d) intestinal permeability. Results were compared with those obtained in 18 normal volunteers. Stool frequency was above the control range in five patients and had increased (p < 0.001) since radiotherapy treatment. Bile acid (p<0.001) vitamin B12(p<0.01) and lactose (p<0.01) absorption were less in the patients when compared with the control subjects. Bile acid adsorption was below the control range in 14 of the 30 patients. Dietary calcium intake was lower (p<0.05) in those patients with lactose malabsorption. Gastric emptying (p<0.01) and small intestinal transit (p<0.01) were more rapid in the patients. Both small intestinal (r=-0.39, p<0.05) and whole gut (r=-0.45) transit were inversely related to stool frequency. Either bowel frequency, bile acid adsorption, vitamin B12 absorption was outside the control range in 19 of the 30 patients. Abnormal gastrointestinal function is essentially an inevitable long-term sequel of pelvic irradiation. 41 refs., 4 figs., 3 tabs.},
doi = {10.1016/0360-3016(93)90202-7},
url = {https://www.osti.gov/biblio/7066198}, journal = {International Journal of Radiation Oncology, Biology and Physics; (United States)},
issn = {0360-3016},
number = ,
volume = 26:2,
place = {United States},
year = {Sat Mar 20 00:00:00 EST 1993},
month = {Sat Mar 20 00:00:00 EST 1993}
}