Radiation effect in mouse skin: Dose fractionation and wound healing
- Haddassah Univ. Hospital, Jerusalem (Israel)
Radiation induced dermal injury was measured by the gain in the physical strength of healing wounds in mouse skin. A sigmoid dose response for the inhibition of wound healing 14 days after surgery was found for single doses of X rays. The sparing of dermal damage from fractionation of the X-ray dose was quantified in terms of the alpha/beta ratio in the linear-quadratic (LQ) model, at a wide range of doses per fraction reaching as low as about 1 Gy. The fit and the appropriateness of the LQ model for the skin wound healing assay was examined with the use of the Fe-plot in which inverse total dose is plotted versus dose per fraction for wound strength isoeffects. The alpha/beta ratio of the skin was about 2.5 Gy (95% confidence of less than +/- 1 Gy) and was appropriate over a dose range of 1 Gy to about 8 Gy. The low alpha/beta value is typical for a late responding tissue. This assay, therefore, has the advantage of measuring and forecasting late radiation responses of the dermis within a short time after irradiation.
- OSTI ID:
- 7062109
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics; (USA), Vol. 18:5; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
SKIN
BIOLOGICAL RADIATION EFFECTS
WOUNDS
HEALING
BIOLOGICAL MODELS
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
MICE
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals