Toxicology and carcinogenesis studies of benzofuran (CAS No. 271-89-6) in F344/N rats and B6C3f1 mice (gavage studies). Technical report series

Technical Report · Sun Oct 01 00:00:00 EDT 1989

OSTI ID:7061762

Irwin, R

Benzofuran is used as an intermediate in the polymerization of coumarone-indene resins found in various corrosion-resistant coatings such as paints and varnishes, in water-resistant coatings for paper products and fabrics, and in adhesives approved for use in food containers. Toxicology and carcinogenesis studies were conducted by administering benzofuran (approximately 99% pure) in corn oil by gavage to groups of F344/N rats and B6C3F1 mice of each sex for 14 days, 13 weeks, or 2 years. Genetic toxicology tests were conducted in Salmonella typhimurium, mouse lymphoma cells, and Chinese hamster ovary (CHO) cells.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 7061762
• Report Number(s): PB-90-231127/XAB; NTP-TR-370
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOFURANS
TOXICITY
BIOASSAY
CARCINOGENESIS
CHEMICAL ANALYSIS
CHO CELLS
LYMPHOMAS
MICE
PROGRESS REPORT
RATS
SALMONELLA TYPHIMURIUM
TABLES
TUMOR CELLS
WEIGHT
ANIMAL CELLS
ANIMALS
BACTERIA
DISEASES
DOCUMENT TYPES
FURANS
HETEROCYCLIC COMPOUNDS
IMMUNE SYSTEM DISEASES
MAMMALS
MICROORGANISMS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOGENESIS
RODENTS
SALMONELLA
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology