6-Bromocholesterol derivatives
Patent
·
OSTI ID:7055982
Novel 6-bromo derivatives of cholesterol have the formula 3-(R-O-),6-BR,17-((H3C-)2-HC-H2C-H2C-H2C-HC(-CH3)-)-ESTR-5-ENE Such compounds are prepared from the known 6-iodocholesterol by treatment with cuprous bromide. These compounds, labelled with radioisotopes of Br-82 or Br-77, are localized in the adrenal, mammary and ovary tissue of female mammals and in the adrenal or prostate tissue of males when administered to such individuals. This provides a method for imaging adrenal, ovary or prostate tissue which is superior to use of the prior art 6-iodo-cholesterol.
- Assignee:
- Merck Frosst Canada Inc. (Canada)
- Patent Number(s):
- US 4430321
- OSTI ID:
- 7055982
- Resource Relation:
- Patent File Date: Filed date 15 Jan 1982; Other Information: PAT-APPL-339265
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CHOLESTEROL
LABELLING
ORGANIC BROMINE COMPOUNDS
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
ADRENAL GLANDS
BROMINE 77
BROMINE 82
MAMMARY GLANDS
OVARIES
PROSTATE
RADIOCHEMISTRY
SEX DEPENDENCE
TISSUE DISTRIBUTION
UPTAKE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE ISOTOPES
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
FEMALE GENITALS
GLANDS
GONADS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MALE GENITALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIOISOTOPES
STEROIDS
STEROLS
SYNTHESIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400700 - Radiochemistry & Nuclear Chemistry
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CHOLESTEROL
LABELLING
ORGANIC BROMINE COMPOUNDS
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
ADRENAL GLANDS
BROMINE 77
BROMINE 82
MAMMARY GLANDS
OVARIES
PROSTATE
RADIOCHEMISTRY
SEX DEPENDENCE
TISSUE DISTRIBUTION
UPTAKE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE ISOTOPES
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
FEMALE GENITALS
GLANDS
GONADS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MALE GENITALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIOISOTOPES
STEROIDS
STEROLS
SYNTHESIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400700 - Radiochemistry & Nuclear Chemistry