Proton nuclear magnetic resonance studies on brain edema

Journal Article · Tue Jun 01 00:00:00 EDT 1982 · J. Neurosurg.; (United States)

DOI:https://doi.org/10.3171/jns.1982.56.6.0747· OSTI ID:7055451

Naruse, S; Horikawa, Y; Tanaka, C; Hirakawa, K; Nishikawa, H; Yoshizaki, K

The water in normal and edematous brain tissues of rats was studied by the pulse nuclear magnetic resonance (NMR) technique, measuring the longitudinal relaxation time (T1) and the transverse relaxation time (T2). In the normal brain, T1 and T2 were single components, both shorter than in pure water. Prolongation and separation of T2 into two components, one fast and one slow, were the characteristic findings in brain edema induced by both cold injury and triethyl tin (TET), although some differences between the two types of edema existed in the content of the lesion and in the degree of changes in T1 and T2 values. Quantitative analysis of T1 and T2 values in their time course relating to water content demonstrated that prolongation of T1 referred to the volume of increased water in tissues examined, and that two phases of T2 reflected the distribution and the content of the edema fluid. From the analysis of the slow component of T2 versus water content during edema formation, it was demonstrated that the increase in edema fluid was steady, and its content was constant during formation of TET-induced edema. On the contrary, during the formation of cold-injury edema, water-rich edema fluid increased during the initial few hours, and protein-rich edema fluid increased thereafter. It was concluded that proton NMR relaxation time measurements may provide new understanding in the field of brain edema research.

• Research Organization: Departments of Neurosurgery, Prefectural University of Medicine, Kyoto, Japan
• OSTI ID: 7055451
• Journal Information: J. Neurosurg.; (United States), Vol. 56:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
BRAIN
EDEMA
PATHOLOGY
BODY FLUIDS
NUCLEAR MAGNETIC RESONANCE
PROTONS
RATS
ANIMALS
BARYONS
BIOLOGICAL MATERIALS
BODY
CENTRAL NERVOUS SYSTEM
ELEMENTARY PARTICLES
FERMIONS
HADRONS
MAGNETIC RESONANCE
MAMMALS
MATERIALS
NERVOUS SYSTEM
NUCLEONS
ORGANS
PATHOLOGICAL CHANGES
RESONANCE
RODENTS
SYMPTOMS
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550900 - Pathology