Second malignancies complicating Hodgkin's disease: a Southwest Oncology Group 10-year followup

Journal Article · Thu Apr 01 00:00:00 EST 1982 · Cancer Treat. Rep.; (United States)

OSTI ID:7054684

Coltman, Jr, C A; Dixon, D O

Thirty-two second malignancies (21 acute leukemias and 11 solid tumors) were identified among 659 patients with all stages of Hodgkin's disease treated by members of the Southwest Oncology Group. There were no leukemias and one solid tumor among 95 patients treated with radiotherapy alone. The actuarial risk of developing acute leukemia at 7 years was 6.2% for chemotherapy alone, 6.4% for combined modality, and 7.7% for salvage chemotherapy. The incidence of acute leukemia was higher (P . 0.002) among those whose treatment began at greater than or equal to 40 years of age. The actuarial risk of leukemia in that group was 20.7% at 7 years. These data are compatible with the hypothesis that chemotherapy alone, combined modality, and salvage chemotherapy have an equivalent oncogenic potential and that patients greater than or equal to 40 years of age have an enhanced susceptibility to these oncogenic stimuli.

• Research Organization: University of Texas Health Sciences Center at San Antonio
• OSTI ID: 7054684
• Journal Information: Cancer Treat. Rep.; (United States), Vol. 66:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
HODGKINS DISEASE
RADIOTHERAPY
CARCINOGENESIS
SIDE EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
LEUKEMIA
MEDICAL SURVEILLANCE
NEOPLASMS
ONCOGENIC TRANSFORMATIONS
PATIENTS
RADIOINDUCTION
RISK ASSESSMENT
STATISTICS
BIOLOGICAL EFFECTS
DISEASES
HEMIC DISEASES
LYMPHOMAS
MATHEMATICS
MEDICINE
NUCLEAR MEDICINE
PATHOGENESIS
RADIATION EFFECTS
RADIOLOGY
SURVEILLANCE
THERAPY
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550603 - Medicine- External Radiation in Therapy- (1980-)