Offspring of patients treated for unilateral Wilms' tumor in childhood
Twenty-seven women and the wives of nine men who survived unilateral Wilms' tumor in childhood had a total of 59 live born offspring. Among the 33 infants born to women who had received orthovoltage abdominal irradiation, ten weighed less than 2500 g at birth and three died during the perinatal period. In addition, one term infant of normal weight died of complications of a breech delivery. Only one of 26 infants born to the wives of Wilms' tumor patients and unirradiated female patients weighed less than 2500 g at birth and none died. The frequency of congenital malformations and spontaneous abortions in this series was not increased, and no offspring has developed cancer. The findings suggest that the risk of Wilms' tumor is low among progeny of survivors of nonfamilial, unilateral lesions. Damage from abdominal irradiation given to girls with Wilms' tumor may predispose them to the subsequent delivery of low birthweight children.
- Research Organization:
- Division of Pediatric Oncology, Sidney Farber Cancer Institute, Boston, Massachusetts
- OSTI ID:
- 7054638
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 49:11
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
INFANTS
GENETIC RADIATION EFFECTS
RADIOSENSITIVITY
RADIOTHERAPY
SIDE EFFECTS
ABDOMEN
ABORTION
COMPARATIVE EVALUATIONS
DIAGNOSIS
EXTERNAL IRRADIATION
MEDICAL SURVEILLANCE
NEOPLASMS
PATIENTS
WEIGHT
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHILDREN
DISEASES
GENETIC EFFECTS
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
SURVEILLANCE
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)