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Title: Slow late myocardial clearance of thallium: a characteristic phenomenon in coronary artery disease

Abstract

Researchers extended the quantitative seven-pinhole method to follow the dynamics of thallium redistribution after exercise. Researchers observed a pattern of slow late thallium clearance that appears to be characteristic of myocardium supplied by obstructed coronary arteries. In 28 subjects, quantitative thallium scintigrams and blood samples for thallium concentration were taken immediately, 2 hours and 4 hours after maximal treadmill exercise. Twenty subjects had coronary artery disease (CAD) and eight were normal. The rate of thallium clearance from the blood (TCB) was compared with the rate of thallium clearance from each segmental region of myocardium between the 2- and 4-hour images. In seven of the eight normal subjects, TCM exceeded TCB in all regions of all images. Seventeen of the 20 CAD patients had at least one region where TCM was less than TCB. Of the 13 patients with multivessel CAD 11 had multiple regions with TCM less than TCB. Using this criterion, we detected 31 of 39 obstructed coronary arteries. Of the 37 regions that were abnormal by this analysis, 30 corresponded to obstructed coronary arteries. In contrast, while conventional circumferential count profile analysis also was abnormal in 17 of the 20 CAD patients, it diagnosed multivessel CAD in onlymore » five of the 13 patients that had it. These results show that slow late thallium clearance from myocardium is characteristic of regions of myocardium supplied by diseased coronary arteries and that observation of this phenomenon may improve diagnostic sensitivity for the presence of multivessel CAD.« less

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Department of Medicine, Veterans Administration Medical Center, Denver, Colorado
OSTI Identifier:
7054408
Resource Type:
Journal Article
Journal Name:
Circulation; (United States)
Additional Journal Information:
Journal Volume: 65:7
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; MYOCARDIUM; SCINTISCANNING; THALLIUM ISOTOPES; RADIONUCLIDE KINETICS; BIOLOGICAL LOCALIZATION; BLOOD CIRCULATION; BLOOD-PLASMA CLEARANCE; CARDIOVASCULAR DISEASES; COMPARATIVE EVALUATIONS; DIAGNOSIS; DIAGNOSTIC USES; MEASURING METHODS; PATIENTS; QUANTITATIVE CHEMICAL ANALYSIS; QUANTITY RATIO; TIME DEPENDENCE; BODY; CARDIOVASCULAR SYSTEM; CHEMICAL ANALYSIS; CLEARANCE; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; HEART; ISOTOPES; MUSCLES; ORGANS; RADIOISOTOPE SCANNING; USES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Sklar, J, Kirch, D, Johnson, T, Hasegawa, B, Peck, S, and Steele, P. Slow late myocardial clearance of thallium: a characteristic phenomenon in coronary artery disease. United States: N. p., 1982. Web. doi:10.1161/01.CIR.65.7.1504.
Sklar, J, Kirch, D, Johnson, T, Hasegawa, B, Peck, S, & Steele, P. Slow late myocardial clearance of thallium: a characteristic phenomenon in coronary artery disease. United States. https://doi.org/10.1161/01.CIR.65.7.1504
Sklar, J, Kirch, D, Johnson, T, Hasegawa, B, Peck, S, and Steele, P. 1982. "Slow late myocardial clearance of thallium: a characteristic phenomenon in coronary artery disease". United States. https://doi.org/10.1161/01.CIR.65.7.1504.
@article{osti_7054408,
title = {Slow late myocardial clearance of thallium: a characteristic phenomenon in coronary artery disease},
author = {Sklar, J and Kirch, D and Johnson, T and Hasegawa, B and Peck, S and Steele, P},
abstractNote = {Researchers extended the quantitative seven-pinhole method to follow the dynamics of thallium redistribution after exercise. Researchers observed a pattern of slow late thallium clearance that appears to be characteristic of myocardium supplied by obstructed coronary arteries. In 28 subjects, quantitative thallium scintigrams and blood samples for thallium concentration were taken immediately, 2 hours and 4 hours after maximal treadmill exercise. Twenty subjects had coronary artery disease (CAD) and eight were normal. The rate of thallium clearance from the blood (TCB) was compared with the rate of thallium clearance from each segmental region of myocardium between the 2- and 4-hour images. In seven of the eight normal subjects, TCM exceeded TCB in all regions of all images. Seventeen of the 20 CAD patients had at least one region where TCM was less than TCB. Of the 13 patients with multivessel CAD 11 had multiple regions with TCM less than TCB. Using this criterion, we detected 31 of 39 obstructed coronary arteries. Of the 37 regions that were abnormal by this analysis, 30 corresponded to obstructed coronary arteries. In contrast, while conventional circumferential count profile analysis also was abnormal in 17 of the 20 CAD patients, it diagnosed multivessel CAD in only five of the 13 patients that had it. These results show that slow late thallium clearance from myocardium is characteristic of regions of myocardium supplied by diseased coronary arteries and that observation of this phenomenon may improve diagnostic sensitivity for the presence of multivessel CAD.},
doi = {10.1161/01.CIR.65.7.1504},
url = {https://www.osti.gov/biblio/7054408}, journal = {Circulation; (United States)},
number = ,
volume = 65:7,
place = {United States},
year = {Tue Jun 01 00:00:00 EDT 1982},
month = {Tue Jun 01 00:00:00 EDT 1982}
}