A constitutive promoter directs expression of the nerve growth factor receptor gene

Journal Article · Mon Aug 01 00:00:00 EDT 1988 · Mol. Cell. Biol.; (United States)

DOI:https://doi.org/10.1128/MCB.8.8.3160· OSTI ID:7040417

Sehgal, A; Patil, N; Chao, M

Expression of nerve growth factor receptor is normally restricted to cells derived from the neural crest in a developmentally regulated manner. The authors analyzed promoter sequences for the human nerve growth factor receptor gene and found that the receptor promoter resembles others which are associated with constitutively expressed genes that have housekeeping and growth-related functions. Unlike these other genes, the initiation of transcription occurred at one major site rather than at multiple sites. The constitutive nature of the nerve growth factor receptor promoter may account for the ability of this gene to be transcribed in a diverse number of heterologous cells after gene transfer. The intron-exon structure of the receptor gene indicated that structural features are precisely divided into discrete domains.

• Research Organization: Dept. of Cell Biology and Anatomy and Div. of Hematology/Oncology, Cornell Univ. Medical College, New York, NY (US)
• OSTI ID: 7040417
• Journal Information: Mol. Cell. Biol.; (United States), Vol. 8:8
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENE OPERONS
DNA SEQUENCING
GROWTH FACTORS
RECEPTORS
GENES
GENE REGULATION
GENE REPRESSORS
NERVE CELLS
PHENOTYPE
RNA PROCESSING
ANIMAL CELLS
MEMBRANE PROTEINS
MITOGENS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PROTEINS
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
550200* - Biochemistry
550400 - Genetics
550800 - Morphology