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Title: Influence of ketamine on regional brain glucose use

Abstract

The purpose of this study was to determine the effect of different doses of ketamine on cerebral function at the level of individual brain structures as reflected by glucose use. Rats received either 5 or 30 mg/kg ketamine intravenously as a loading dose, followed by an infusion to maintain a steady-state level of the drug. An additional group received 30 mg/kg as a single injection only, and was studied 20 min later, by which time they were recovering consciousness (withdrawal group). Regional brain energy metabolism was evaluated with (6-/sup 14/C)glucose and quantitative autoradiography during a 5-min experimental period. A subhypnotic, steady-state dose (5 mg/kg) of ketamine caused a stimulation of glucose use in most brain areas, with an average increase of 20%. At the larger steady-state dose (30 mg/kg, which is sufficient to cause anesthesia), there was no significant effect on most brain regions; some sensory nuclei were depressed (inferior colliculus, -29%; cerebellar dentate nucleus, -18%; vestibular nucleus, -16%), but glucose use in the ventral posterior hippocampus was increased by 33%. In contrast, during withdrawal from a 30-mg/kg bolus, there was a stimulation of glucose use throughout the brain (21-78%), at a time when plasma ketamine levels were similar tomore » the levels in the 5 mg/kg group. At each steady-state dose, as well as during withdrawal, ketamine caused a notable stimulation of glucose use by the hippocampus.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Pennsylvania State Univ., Hershey (USA)
OSTI Identifier:
7040131
Resource Type:
Journal Article
Journal Name:
Anesthesiology; (United States)
Additional Journal Information:
Journal Volume: 69:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANESTHETICS; BIOLOGICAL EFFECTS; GLUCOSE; METABOLISM; AUTORADIOGRAPHY; BRAIN; CARBON 14 COMPOUNDS; HIPPOCAMPUS; INTRAVENOUS INJECTION; RATS; SPECTROPHOTOMETRY; ALDEHYDES; ANIMALS; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUGS; HEXOSES; INJECTION; INTAKE; LABELLED COMPOUNDS; MAMMALS; MONOSACCHARIDES; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; RODENTS; SACCHARIDES; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Davis, D W, Mans, A M, Biebuyck, J F, and Hawkins, R A. Influence of ketamine on regional brain glucose use. United States: N. p., 1988. Web. doi:10.1097/00000542-198808000-00008.
Davis, D W, Mans, A M, Biebuyck, J F, & Hawkins, R A. Influence of ketamine on regional brain glucose use. United States. https://doi.org/10.1097/00000542-198808000-00008
Davis, D W, Mans, A M, Biebuyck, J F, and Hawkins, R A. 1988. "Influence of ketamine on regional brain glucose use". United States. https://doi.org/10.1097/00000542-198808000-00008.
@article{osti_7040131,
title = {Influence of ketamine on regional brain glucose use},
author = {Davis, D W and Mans, A M and Biebuyck, J F and Hawkins, R A},
abstractNote = {The purpose of this study was to determine the effect of different doses of ketamine on cerebral function at the level of individual brain structures as reflected by glucose use. Rats received either 5 or 30 mg/kg ketamine intravenously as a loading dose, followed by an infusion to maintain a steady-state level of the drug. An additional group received 30 mg/kg as a single injection only, and was studied 20 min later, by which time they were recovering consciousness (withdrawal group). Regional brain energy metabolism was evaluated with (6-/sup 14/C)glucose and quantitative autoradiography during a 5-min experimental period. A subhypnotic, steady-state dose (5 mg/kg) of ketamine caused a stimulation of glucose use in most brain areas, with an average increase of 20%. At the larger steady-state dose (30 mg/kg, which is sufficient to cause anesthesia), there was no significant effect on most brain regions; some sensory nuclei were depressed (inferior colliculus, -29%; cerebellar dentate nucleus, -18%; vestibular nucleus, -16%), but glucose use in the ventral posterior hippocampus was increased by 33%. In contrast, during withdrawal from a 30-mg/kg bolus, there was a stimulation of glucose use throughout the brain (21-78%), at a time when plasma ketamine levels were similar to the levels in the 5 mg/kg group. At each steady-state dose, as well as during withdrawal, ketamine caused a notable stimulation of glucose use by the hippocampus.},
doi = {10.1097/00000542-198808000-00008},
url = {https://www.osti.gov/biblio/7040131}, journal = {Anesthesiology; (United States)},
number = ,
volume = 69:2,
place = {United States},
year = {Mon Aug 01 00:00:00 EDT 1988},
month = {Mon Aug 01 00:00:00 EDT 1988}
}