Cancer risk-specific dose estimate for 2,3,7,8-TCDD: appendices A through F. Draft report
This draft report reexamines the scientific basis and methods used by the U.S. Environmental Protection Agency (EPA) for estimating the cancer potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). It focuses on the hazard identification and dose-response assessment for the potential human carcinogenicity of this chemical. The objective of the report is to determine if EPA's 1985 cancer risk assessment for polychlorinated dibenzo-p-dioxins should be modified in light of recent data, alternative risk assessment methods, or alternative interpretations of data on the chemical. The report concludes that (1) the 1985 assessment that associates a 0.006 pk/kg/day dose with a plausible upper-bound increased cancer risk of one in a million should be reconsidered, and (2) a change to a 0.1 pg/kg/day dose as a plausible upper bound associated with an increased lifetime risk of one in a million is consistent with the available data and theories, and represents a reasonable science policy for the Agency. Appendices A through F to the document contain important background information on a broad range of issues related to 2,3,7,8-TCDD including quantitative implications (A), epidemiology (B and D), reproductive and developmental toxicity (C), immunotoxicity (E), and mechanisms of action (F).
- Research Organization:
- Environmental Protection Agency, Washington, DC (USA). Office of Health and Environmental Assessment
- OSTI ID:
- 7037952
- Report Number(s):
- PB-88-231212/XAB
- Resource Relation:
- Other Information: See also report dated Jun 1988, PB--88-231204
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
CARCINOGENS
DIOXIN
CHLORINATED AROMATIC HYDROCARBONS
HAZARDOUS MATERIALS
EPIDEMIOLOGY
RISK ASSESSMENT
TOXICITY
AROMATICS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOGENESIS
550900* - Pathology