Mutation induction by very low dose rate gamma rays in cultured mouse leukemia cells L5178Y

Journal Article · Mon Aug 01 00:00:00 EDT 1988 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577163· OSTI ID:7037541

Furuno-Fukushi, I; Ueno, A M; Matsudaira, H

Induction of cell killing and mutation to 6-thioguanine resistance was studied in growing mouse leukemia cells in culture following gamma rays at dose rates of 30 Gy/h, 20 cGy/h, and 6.3 mGy/h, i.e., acute, low dose rate, and very low dose rate irradiation. A marked increase was observed in the cell survival with decreasing dose rate; no reduction in the surviving fraction was detected after irradiation at 6.3 mGy/h until a total dose of 4 Gy. Similarly, the induced mutation frequency decreased after low dose rate irradiation compared to acute irradiation. However, the frequency after irradiation at 6.3 mGy/h was unexpectedly high and remained at a level which was intermediate between acute and low dose rate irradiation. No appreciable changes were observed in the responses to acute gamma rays (in terms of cell killing and mutation induction) in the cells which had experienced very low dose rate irradiation.

• Research Organization: National Institute of Radiological Sciences, Chiba-shi (Japan)
• OSTI ID: 7037541
• Journal Information: Radiat. Res.; (United States), Vol. 115:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL KILLING
RADIOINDUCTION
MUTATIONS
TUMOR CELLS
GENETIC RADIATION EFFECTS
CELL CULTURES
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
GAMMA RADIATION
LEUKEMIA
LOW DOSE IRRADIATION
MICE
MUTATION FREQUENCY
RADIATION DOSES
SURVIVAL TIME
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEOPLASMS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture