Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28
Journal Article
·
· Genomics; (United States)
- Brigham and Women's Hospital, Boston, MA (United States) Dana-Farber Cancer Institute, Boston, MA (United States)
- Brigham and Women's Hospital, Boston, MA (United States)
- Emory Univ. School of Medicine, Atlanta, GA (United States)
- International Institute of Genetics and Biophysics, Naples, (Italy)
- Children's Hospital, Boston, MA (United States)
Actin-binding protein-280 (ABP-280) is a dimeric actin filament-crosslinking protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. The authors have mapped the ABP-280 filamin gene (FLN) to Xq28 by Southern blot analysis of somatic cell hybrid lines, by fluorescence in situ hybridization, and through identification of portions of the FLN gene within cosmids and YACs mapped to Xq28. The FLN gene is found within a 200-kb region centromeric to the G6PD locus and telomeric to DSX52 and the color vision locus. 23 refs., 2 figs.
- OSTI ID:
- 7035439
- Journal Information:
- Genomics; (United States), Vol. 17:2; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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