Comparison of SPECT imaging using monoclonal antibodies with computed tomography (CT) and ultrasonography (US) for detection of recurrences of colorectal carcinoma: A prospective clinical study
A prospective clinical study compared SPECT imaging, ultrasonography (US), and computed tomography (CT) in 22 patients clinically or biologically (increased CEA and/or CA 19-9 serum concentration) suspected of recurrence of colorectal carcinoma. The recordings were performed 3 to 5 days after injection of 111 to 129.5 MBq of cocktail of I-131-labeled anti-CEA and 19-9 (F(ab')2 fragments) monoclonal antibodies. Twenty nine tumor sites were demonstrated by surgery or concordant results of conventional diagnostic methods. SPECT visualized 21 of these 29 tumor sites (72%). It was negative in 4 cases with no demonstrated recurrence (by any method and follow-up). With respect to localization of tumor sites, SPECT visualized 7/12 liver metastases, 8/8 local pelvic recurrences and 6/8 abdominal recurrences. CT and US, systematically performed blind after SPECT, respectively visualized 9/10 and 9/12 liver metastases, 7/12 and 4/13 pelvic and abdominal recurrences. Image interpretation of SPECT was difficult due to poor tumor contrast and the large number of low-intensity, nonspecific radioactive foci. A focus had to recur in at least 3 successive slices to be considered pathological. Four tumor sites were visualized with SPECT and not with US and CT (negative or uncertain results). SPECT would appear to be useful for localizing pelvic or abdominal recurrences in cases in which interpretation of US and CT images is difficult, often because their nonspecific approach does not make it possible to differentiate a tumor recurrence from post-operative anatomical changes.
- Research Organization:
- Centre Rene Gauducheau, NANTES
- OSTI ID:
- 7032008
- Report Number(s):
- CONF-850611-; TRN: 87-010654
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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