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Title: High incidence of vesicoureteric reflux in asymptomatic siblings of children with known reflux

Abstract

A significant occurrence of vesicoureteric reflux in siblings of children with reflux has been previously suggested. The purpose of this study was to evaluate the incidence of vesicoureteric reflux in asymptomatic siblings of children with vesicoureteric reflux using radionuclide voiding cystography (RNC). A random group of 52 siblings was studied. Their ages were from 2 mos. to 13 yrs. (mean 4 yrs.). Seventy-one percent were female and 29% male, RNC was performed with the patients supine, and Tc-99m pertechnetate (2mCi/1) was infused into the bladder by catheter. A computerized gamma camera recorded the filling and voiding phase of the study at 1 frame/5 sec. Reflux was detected in 40% of the patients. It was bilateral in 17% and unilateral in 23% of the patients. Reflux was identified to the renal pelves in half of the patients. In two of these patients Tc-99m DMSA scans were obtained which revealed significant renal scarring. This study demonstrates the high incidence of reflux of various degrees in these asymptomatic siblings on high risk of developing significant renal disease. Identification and proper treatment of asymptomatic children with vesicoureteric reflux may help prevent the development of renal damage.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
The Children's Hospital and Harvard Medical School, Boston, MA
OSTI Identifier:
7031649
Report Number(s):
CONF-850611-
Journal ID: CODEN: JNMEA; TRN: 87-010689
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; KIDNEYS; DYNAMIC FUNCTION STUDIES; RADIONUCLIDE KINETICS; SCINTISCANNING; TECHNETIUM 99; DIAGNOSTIC USES; UROGENITAL SYSTEM DISEASES; DIAGNOSIS; DISEASE INCIDENCE; BIOLOGICAL FUNCTIONS; CHILDREN; DAMAGE; EVALUATION; EXCRETION; GAMMA CAMERAS; PEDIATRICS; PHOTON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; RENAL CLEARANCE; RETENTION FUNCTIONS; URINARY TRACT; AGE GROUPS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CAMERAS; CLEARANCE; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; FUNCTIONS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TOMOGRAPHY; USES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Treves, S T, Van den Abbeele, A D, Davis, R T, Rosen, P, Bauer, S, Retik, A, and Colodny, A. High incidence of vesicoureteric reflux in asymptomatic siblings of children with known reflux. United States: N. p., 1985. Web.
Treves, S T, Van den Abbeele, A D, Davis, R T, Rosen, P, Bauer, S, Retik, A, & Colodny, A. High incidence of vesicoureteric reflux in asymptomatic siblings of children with known reflux. United States.
Treves, S T, Van den Abbeele, A D, Davis, R T, Rosen, P, Bauer, S, Retik, A, and Colodny, A. 1985. "High incidence of vesicoureteric reflux in asymptomatic siblings of children with known reflux". United States.
@article{osti_7031649,
title = {High incidence of vesicoureteric reflux in asymptomatic siblings of children with known reflux},
author = {Treves, S T and Van den Abbeele, A D and Davis, R T and Rosen, P and Bauer, S and Retik, A and Colodny, A},
abstractNote = {A significant occurrence of vesicoureteric reflux in siblings of children with reflux has been previously suggested. The purpose of this study was to evaluate the incidence of vesicoureteric reflux in asymptomatic siblings of children with vesicoureteric reflux using radionuclide voiding cystography (RNC). A random group of 52 siblings was studied. Their ages were from 2 mos. to 13 yrs. (mean 4 yrs.). Seventy-one percent were female and 29% male, RNC was performed with the patients supine, and Tc-99m pertechnetate (2mCi/1) was infused into the bladder by catheter. A computerized gamma camera recorded the filling and voiding phase of the study at 1 frame/5 sec. Reflux was detected in 40% of the patients. It was bilateral in 17% and unilateral in 23% of the patients. Reflux was identified to the renal pelves in half of the patients. In two of these patients Tc-99m DMSA scans were obtained which revealed significant renal scarring. This study demonstrates the high incidence of reflux of various degrees in these asymptomatic siblings on high risk of developing significant renal disease. Identification and proper treatment of asymptomatic children with vesicoureteric reflux may help prevent the development of renal damage.},
doi = {},
url = {https://www.osti.gov/biblio/7031649}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 26:5,
place = {United States},
year = {Wed May 01 00:00:00 EDT 1985},
month = {Wed May 01 00:00:00 EDT 1985}
}

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