Normal variation of radionuclide esophageal transit
The authors have extended their investigation of normal esophageal transit of aqueous Tc-99m sulfur colloid to determine range and reproducibility using previously described methods. They studied 5 males and 11 females, ages 21 to 67 (mean 35), with no symptoms of esophageal disease. Eight had repeat studies after a 48 day mean interval. The rapid component mean transit time through the esophagus in the 1st swallow (MTT), residual fraction after the 1st and 4th swallows (RF(1), RF(4)), and retrograde index quantifying retrograde motion in the 1st swallow (RI) are presented for the 16 initial studies. CV/sub i/ = intersubject coefficient of variation. CV/sub r/=mean intrasubject coefficient of variation of the 8 repeat pairs. Marked skewness of the distribution to the right, as well as high inter- and intrasubject variation, are noted for RF(1) and RI. Condensed images having a spatial and a temporal dimension show related variable qualitative features. In contrast, MTT distribution is somewhat symmetrical with lower variation, and RF(4) is intermediate. The authors conclude that the normal 1st swallow is subject to sporadic variation. Though all the measured indices may have diagnostic utility, certain of those having a lesser degree of normal variation, notably the residual fractions of swallows beyond the 1st, may discriminate better between normal and abnormal than do RF(1) and RI.
- Research Organization:
- Univ. of Pittsburgh School of Medicine, Pittsburgh, PA
- OSTI ID:
- 7031094
- Report Number(s):
- CONF-850611-; TRN: 87-010748
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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BETA-MINUS DECAY RADIOISOTOPES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics